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GAD1

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]

Full Name

Glutamate Decarboxylase 1

Function

Catalyzes the production of GABA.

Biological Process

Chemical synaptic transmission Source: ProtInc
Gamma-aminobutyric acid biosynthetic process Source: Ensembl
Glutamate catabolic process Source: UniProtKB
Glutamate decarboxylation to succinate Source: ProtInc
Locomotory exploration behavior Source: Ensembl
Neurotransmitter biosynthetic process Source: UniProtKB-KW
Protein-pyridoxal-5-phosphate linkage Source: UniProtKB
Response to drug Source: Ensembl
Social behavior Source: Ensembl

Cellular Location

Plasma membrane; Axon terminus; Cell cortex; Clathrin-sculpted gamma-aminobutyric acid transport vesicle; Inhibitory synapse; Presynaptic active zone; Vesicle membrane

Involvement in disease

Cerebral palsy, spastic quadriplegic 1 (CPSQ1):
A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay, mental retardation and sometimes epilepsy can be part of the clinical picture.

Anti-GAD1 antibodies

Mouse Anti-GAD1 Recombinant Antibody (120G4) (CBMAB-G1701-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat

Clone: 120G4

Application*: IP, IC

Mouse Anti-GAD1 Recombinant Antibody (13k26) (CBMAB-G1703-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: 13k26

Application*: E

Mouse Anti-GAD1 Recombinant Antibody (14) (CBMAB-G1704-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 14

Application*: WB

Mouse Anti-GAD1 Recombinant Antibody (1D12) (CBMAB-G1706-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human

Clone: 1D12

Application*: E, WB

Mouse Anti-GAD1 Recombinant Antibody (2911) (CBMAB-G1707-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: 2911

Application*: WB

Mouse Anti-GAD1 Recombinant Antibody (2919) (CBMAB-G1708-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: 2919

Application*: WB

Mouse Anti-GAD1 Recombinant Antibody (3H2) (CBMAB-G1710-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 3H2

Application*: IC/IF, IH, P, WB

Mouse Anti-GAD1 Recombinant Antibody (5E11) (CBMAB-G1713-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 5E11

Application*: E, WB

Mouse Anti-GAD1 Recombinant Antibody (9A6) (CBMAB-G1714-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 9A6

Application*: IH, WB

Mouse Anti-GAD1 Recombinant Antibody (K-87) (CBMAB-G1719-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Human

Clone: K-87

Application*: FC, ICC/IF, IHC-Fr, IHC-P, WB

Mouse Anti-GAD1 Recombinant Antibody (CBLG1-2521) (CBMAB-G1720-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Monkey

Clone: CBLG1-2521

Application*: WB

Mouse Anti-GAD1 Recombinant Antibody (CBLG1-2522) (CBMAB-G1721-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Dog

Clone: CBLG1-2522

Application*: WB

Mouse Anti-GAD1 Recombinant Antibody (CBLG1-2523) (CBMAB-G1722-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-2523

Application*: WB

Mouse Anti-GAD1 Recombinant Antibody (CBLG1-467) (CBMAB-G1723-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBLG1-467

Application*: IC, IP

Mouse Anti-GAD1 Recombinant Antibody (CBLG1-468) (CBMAB-G1724-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Rat

Clone: CBLG1-468

Application*: P, WB

Mouse Anti-GAD1 Recombinant Antibody (CBLG1-469) (CBMAB-G1725-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Rat

Clone: CBLG1-469

Application*: IH, WB

Mouse Anti-GAD1 Recombinant Antibody (CBLG1-472) (CBMAB-G1728-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Monkey

Clone: CBLG1-472

Application*: IH, WB

Mouse Anti-GAD1 Monoclonal Antibody (3G9) (CBMAB-1314-YC)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Monkey

Clone: 3G9

Application*: IC, IF, IH, P, IP, WB

Mouse Anti-GAD1 Recombinant Antibody (CBFYH-0221) (CBMAB-H1090-FY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBFYH-0221

Application*: WB, IH

Mouse Anti-GAD1 Recombinant Antibody (252910) (CBMAB-G0137-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 252910

Application*: WB

Mouse Anti-GAD1 Recombinant Antibody (CBLG1-022) (CBMAB-G0139-LY)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Rat

Clone: CBLG1-022

Application*: IH, WB

Rabbit Anti-GAD1 Recombinant Antibody (A9A5X) (CBMAB-CP0789-LY)

SDS

Target: GAD1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Rat, Human, Mouse

Clone: A9A5X

Application*: IF

Rabbit Anti-GAD1 Recombinant Antibody (D1F2M) (CBMAB-CP0790-LY)

SDS

Target: GAD1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: D1F2M

Application*: WB, IP, IF

Mouse Anti-GAD1 Recombinant Antibody (5D8) (CBMAB-1552-CN)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5D8

Application*: WB, IH

Mouse Anti-GAD1 Recombinant Antibody (CL2911) (CBMAB-1553-CN)

SDS

Target: GAD1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CL2911

Application*: WB, IH

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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