GALR3

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]

Full Name

Galanin Receptor 3

Function

Receptor for the hormone galanin (PubMed:25691535).

Receptor for the hormone spexin-1 (PubMed:24517231).

Biological Process

Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: ProtInc
Feeding behavior Source: ProtInc
Galanin-activated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Learning or memory Source: ProtInc
Negative regulation of adenylate cyclase activity Source: InterPro
Neuropeptide signaling pathway Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 1-20
Helical: 21-41
Cytoplasmic: 42-57
Helical: 58-78
Extracellular: 79-96
Helical: 97-118
Cytoplasmic: 119-138
Helical: 139-159
Extracellular: 160-184
Helical: 185-205
Cytoplasmic: 206-236
Helical: 237-257
Extracellular: 258-259
Helical: 260-280
Cytoplasmic: 281-368