GBGT1

This gene encodes a glycosyltransferase that plays a role in the synthesis of Forssman glycolipid (FG), a member of the globoseries glycolipid family. Glycolipids such as FG form attachment sites for the binding of pathogens to cells; expression of this protein may determine host tropism to microorganisms. Alternative splicing results in multiple transcript variants.
Full Name
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Function
Has lost the ability to synthesize Forssman glycolipid antigen (FORS1/FG) (PubMed:10506200).

Might have acquired an alternative function in glycosphingolipid metabolism, but it remains to be established. It appears to have drifted more slowly than confirmed pseudogenes in the glycosyltransferase 6 family, suggesting that it has remained under evolutionary pressure.
Biological Process
Carbohydrate metabolic process Source: InterPro
Glycolipid biosynthetic process Source: ProtInc
Lipid glycosylation Source: GO_Central
Protein glycosylation Source: UniProtKB-UniPathway
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-5
Helical: 6-26
Lumenal: 27-347
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Anti-GBGT1 antibodies

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Rat Anti-GBGT1 Recombinant Antibody (FOM-1) (CBMAB-G2409-LY)

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Target: GBGT1
Host: Rat
Antibody Isotype: IgM
Specificity: Mouse
Clone: FOM-1
Application*: C, P
Datasheet SDS

Rat Anti-GBGT1 Recombinant Antibody (33B12) (CBMAB-G2407-LY)

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Target: GBGT1
Host: Rat
Antibody Isotype: IgG2c
Specificity: Mouse
Clone: 33B12
Application*: C
Datasheet SDS

Rat Anti-GBGT1 Recombinant Antibody (117C9) (CBMAB-G2406-LY)

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Target: GBGT1
Host: Rat
Antibody Isotype: IgM
Specificity: Mouse
Clone: 117C9
Application*: C
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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