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GBGT1

This gene encodes a glycosyltransferase that plays a role in the synthesis of Forssman glycolipid (FG), a member of the globoseries glycolipid family. Glycolipids such as FG form attachment sites for the binding of pathogens to cells; expression of this protein may determine host tropism to microorganisms. Alternative splicing results in multiple transcript variants.

Full Name

globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

Function

Has lost the ability to synthesize Forssman glycolipid antigen (FORS1/FG) (PubMed:10506200).

Might have acquired an alternative function in glycosphingolipid metabolism, but it remains to be established. It appears to have drifted more slowly than confirmed pseudogenes in the glycosyltransferase 6 family, suggesting that it has remained under evolutionary pressure.

Biological Process

Carbohydrate metabolic process Source: InterPro
Glycolipid biosynthetic process Source: ProtInc
Lipid glycosylation Source: GO_Central
Protein glycosylation Source: UniProtKB-UniPathway

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-5
Helical: 6-26
Lumenal: 27-347

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Anti-GBGT1 antibodies

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Rat Anti-GBGT1 Recombinant Antibody (FOM-1) (CBMAB-G2409-LY)

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Target: GBGT1

Host: Rat

Antibody Isotype: IgM

Specificity: Mouse

Clone: FOM-1

Application*: C, P

Rat Anti-GBGT1 Recombinant Antibody (33B12) (CBMAB-G2407-LY)

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Target: GBGT1

Host: Rat

Antibody Isotype: IgG2c

Specificity: Mouse

Clone: 33B12

Application*: C

Rat Anti-GBGT1 Recombinant Antibody (117C9) (CBMAB-G2406-LY)

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Target: GBGT1

Host: Rat

Antibody Isotype: IgM

Specificity: Mouse

Clone: 117C9

Application*: C

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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