GC
The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Full Name
GC, Vitamin D Binding Protein
Function
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Biological Process
Vitamin D metabolic process Source: Ensembl
Vitamin transport Source: ProtInc
Vitamin transport Source: ProtInc
Cellular Location
Secreted
PTM
Allele GC*1S is O-glycosylated at Thr-436 (PubMed:20079467). The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated (PubMed:17360250). The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated.
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Anti-GC antibodies
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Target: GC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-743
Application*: E, P, WB
Target: GC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2B12
Application*: P, WB
Target: GC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DBP5H08
Application*: DB, WB
Target: Gc
Sensitivity: 1.1 μg/mL
Detection Range: 2-600 μg/mL
Sample Type: Serum, Plasma, Urine, Ascites, Cerebrospinal fluid, Tissue
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Compare
Target: gC
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 28-447
Tag: His Tag
Compare
Target: gC
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 91-447
Tag: His Tag
Target: gC
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 567-999
Tag: His Tag
Target: GC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-743
Application*: IH
Target: GC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: G0253
Application*: WB, IF
Target: GC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: V0184
Application*: IH
Target: GC
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: V0183
Application*: E
Target: GC
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: V0181
Application*: E
Target: GC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V0036
Application*: WB, IF, P, F
Target: GC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF179
Application*: ELISA, WB
Target: GC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: M81485-B
Application*: E
Target: GC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: M81485
Application*: WB, E
Target: GC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: M81443
Application*: E
Target: GC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EP2923Y
Application*: WB, P, F, IC/IF
Target: GC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2G2
Application*: WB
Target: GC
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 19E8
Application*: E, P
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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