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GC

The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Full Name
GC, Vitamin D Binding Protein
Function
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Biological Process
Vitamin D metabolic process Source: Ensembl
Vitamin transport Source: ProtInc
Cellular Location
Secreted
PTM
Allele GC*1S is O-glycosylated at Thr-436 (PubMed:20079467). The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated (PubMed:17360250). The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated.

Anti-GC antibodies

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Target: GC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DBP5H08
Application*: DB, WB
Target: GC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2B12
Application*: P, WB
Target: GC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-743
Application*: E, P, WB
Target: GC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF179
Application*: ELISA, WB
Target: GC
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 19E8
Application*: E, P
Target: GC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G2
Application*: WB, E
Target: GC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EP2923Y
Application*: WB, P, F, IC/IF
Target: GC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: M81443
Application*: E
Target: GC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: M81485
Application*: WB, E
Target: GC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: M81485-B
Application*: E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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