GC

The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Full Name
GC, Vitamin D Binding Protein
Function
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Biological Process
Vitamin D metabolic process Source: Ensembl
Vitamin transport Source: ProtInc
Cellular Location
Secreted
PTM
Allele GC*1S is O-glycosylated at Thr-436 (PubMed:20079467). The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated (PubMed:17360250). The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated.
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Anti-GC antibodies

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Mouse Anti-GC Recombinant Antibody (CBLG1-743) (CBMAB-G2483-LY)

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Target: GC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-743
Application*: E, P, WB
Datasheet SDS

Mouse Anti-GC Recombinant Antibody (2B12) (CBMAB-G2472-LY)

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Target: GC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2B12
Application*: P, WB
Datasheet SDS

Mouse Anti-GC Recombinant Antibody (DBP5H08) (CBMAB-G0253-LY)

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Target: GC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DBP5H08
Application*: DB, WB
Datasheet SDS

GC Matched Antibody Pair (470) (APMAB-470LY)

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Target: GC
Specificity: Human
Datasheet SDS

Mouse Anti-GC Recombinant Antibody (CF179) (CBMAB-FT062LY)

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Target: GC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF179
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-GC Recombinant Antibody (M81485-B) (CBMAB-V0184-LY)

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Target: GC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: M81485-B
Application*: E
Datasheet SDS

Mouse Anti-GC Recombinant Antibody (M81485) (CBMAB-V0183-LY)

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Target: GC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: M81485
Application*: WB, E
Datasheet SDS

Mouse Anti-GC Recombinant Antibody (M81443) (CBMAB-V0181-LY)

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Target: GC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: M81443
Application*: E
Datasheet SDS

Rabbit Anti-GC Recombinant Antibody (EP2923Y) (CBMAB-V0036-LY)

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Target: GC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EP2923Y
Application*: WB, P, F, IC/IF
Datasheet SDS

Mouse Anti-GC Recombinant Antibody (2G2) (CBMAB-V0014-LY)

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Target: GC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G2
Application*: WB, E
Datasheet SDS

Mouse Anti-GC Recombinant Antibody (19E8) (CBMAB-V0005-LY)

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Target: GC
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 19E8
Application*: E, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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