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Mouse Anti-GC Recombinant Antibody (2B12) (CBMAB-G2472-LY)

This product is antibody recognizes GC. The antibody 2B12 immunoassay techniques such as: IHC-P, WB.
See all GC antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B12
Antibody Isotype
IgG2b, κ
Application
IHC-P, WB

Basic Information

Immunogen
Protein purified from Human plasma
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol, 0.15M NaCl
Preservative
0.03% sodium azide, 0.01% BSA
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GC, Vitamin D Binding Protein
Introduction
The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Entrez Gene ID
2638
UniProt ID
P02774
Alternative Names
GC; Vitamin D Binding Protein; Vitamin D-Binding Protein-Macrophage Activating Factor; Group-Specific Component (Vitamin D Binding Protein); Gc Protein-Derived Macrophage Activating Factor; Gc-Globulin; DBP-Maf; Gc-MAF; GcMAF; DBP; VDB; Epididymis Secretory Protein Li 51;
Function
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Biological Process
Vitamin D metabolic process Source: Ensembl
Vitamin transport Source: ProtInc
Cellular Location
Secreted
PTM
Allele GC*1S is O-glycosylated at Thr-436 (PubMed:20079467). The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated (PubMed:17360250). The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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