GLYAT

The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

glycine-N-acyltransferase

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.

Acyl-CoA metabolic process Source: ProtInc
Benzoyl-CoA metabolic process Source: UniProtKB
Glycine metabolic process Source: UniProtKB
Monocarboxylic acid metabolic process Source: UniProtKB
Response to toxic substance Source: ProtInc
Xenobiotic metabolic process Source: Reactome

Mitochondrion