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GPR17

Full Name

G protein-coupled receptor 17

Function

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Biological Process

G protein-coupled receptor signaling pathway Source: ProtInc
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of Rho protein signal transduction Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-64
Helical: 65-85
Cytoplasmic: 86-92
Helical: 93-113
Extracellular: 114-133
Helical: 134-154
Cytoplasmic: 155-175
Helical: 176-196
Extracellular: 197-223
Helical: 224-244
Cytoplasmic: 245-260
Helical: 261-281
Extracellular: 282-308
Helical: 309-329
Cytoplasmic: 330-367

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Anti-GPR17 antibodies

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Mouse Anti-GPR17 Recombinant Antibody (3C10) (V2LY-0226-LY852)

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Target: GPR17

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: 3C10

Application*: E, IP, IF, WB

Mouse Anti-GPR17 Recombinant Antibody (EG1390) (CBMAB-EN1669-LY)

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Target: GPR17

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: EG1390

Application*: IH

Mouse Anti-GPR17 Recombinant Antibody (CBLG1-3203) (CBMAB-G4639-LY)

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Target: GPR17

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: CBLG1-3203

Application*: WB, IH

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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