GPR37

This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]

Full Name

G Protein-Coupled Receptor 37

Function

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ParkinsonsUK-UCL
Dopamine biosynthetic process Source: Ensembl
G protein-coupled receptor signaling pathway Source: ProtInc
Locomotion involved in locomotory behavior Source: Ensembl
Negative regulation of hydrogen peroxide-induced cell death Source: ParkinsonsUK-UCL
Neuropeptide signaling pathway Source: UniProtKB
Positive regulation of dopamine metabolic process Source: Ensembl
Positive regulation of MAPK cascade Source: ParkinsonsUK-UCL

Cellular Location

Endoplasmic reticulum membrane; Cell membrane

Topology

Extracellular: 27-265
Helical: 266-286
Cytoplasmic: 287-299
Helical: 300-320
Extracellular: 321-335
Helical: 336-356
Cytoplasmic: 357-379
Helical: 380-400
Extracellular: 401-443
Helical: 444-464
Cytoplasmic: 465-493
Helical: 494-514
Extracellular: 515-531
Helical: 532-552
Cytoplasmic: 553-613

PTM

Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.