Human Recombinant GPR37 protein, His Tag (V2LY-0526-LY4395)

Name: Human Recombinant GPR37 protein, His Tag
SKU: V2LY-0526-LY4395
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant GPR37 protein, His Tag consist of Amino Acid: 1-265 and predicts a molecular mass of 26.6 kDa.

Molecule Mass

26.6 kDa

Sequence

Amino Acid: 1-265

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>80% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

G Protein-Coupled Receptor 37

Function

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ParkinsonsUK-UCL
Dopamine biosynthetic process Source: Ensembl
G protein-coupled receptor signaling pathway Source: ProtInc
Locomotion involved in locomotory behavior Source: Ensembl
Negative regulation of hydrogen peroxide-induced cell death Source: ParkinsonsUK-UCL
Neuropeptide signaling pathway Source: UniProtKB
Positive regulation of dopamine metabolic process Source: Ensembl
Positive regulation of MAPK cascade Source: ParkinsonsUK-UCL

Cellular Location

Endoplasmic reticulum membrane; Cell membrane

Topology

Extracellular: 27-265
Helical: 266-286
Cytoplasmic: 287-299
Helical: 300-320
Extracellular: 321-335
Helical: 336-356
Cytoplasmic: 357-379
Helical: 380-400
Extracellular: 401-443
Helical: 444-464
Cytoplasmic: 465-493
Helical: 494-514
Extracellular: 515-531
Helical: 532-552
Cytoplasmic: 553-613

PTM

Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.

Sohel, M. S. H., Homma, T., Onouchi, S., & Saito, S. (2023). Expression patterns of prosaposin and its receptors, G protein–coupled receptor (GPR) 37 and GPR37L1 mRNAs, in the chick inner ear. Cell and Tissue Research, 1-17.

Fuyuki, A., Yamamoto, S., Sohel, M. S. H., Homma, T., Kitamura, K., Onouchi, S., & Saito, S. (2023). Expression of prosaposin and its G protein-coupled receptor (GPR) 37 in mouse cochlear and vestibular nuclei. Journal of Veterinary Medical Science, 85(3), 266-270.

Kitamura, K., Homma, T., Sohel, M. S. H., Fuyuki, A., Miyawaki, S., Onouchi, S., & Saito, S. (2023). Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ. Tissue and Cell, 82, 102093.

Marazziti, D. (2023). GPR37 and Related Receptors: Disease Regulation. International Journal of Molecular Sciences, 24(7), 6722.

He, F., Gao, F., Cai, N., Jiang, M., & Wu, C. (2022). Chlorogenic acid enhances alveolar macrophages phagocytosis in acute respiratory distress syndrome by activating G protein-coupled receptor 37 (GPR 37). Phytomedicine, 107, 154474.

Massimi, M., Di Pietro, C., La Sala, G., & Matteoni, R. (2022). Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications. International Journal of Molecular Sciences, 23(8), 4288.

An, J., Zhang, Y., Fudge, A. D., Lu, H., Richardson, W. D., & Li, H. (2021). G protein‐coupled receptor GPR37‐like 1 regulates adult oligodendrocyte generation. Developmental Neurobiology, 81(8), 975-984.

Sarkar, S., Homma, T., Onouchi, S., Shimizu, Y., Shiina, T., Nabeka, H., ... & Saito, S. (2021). Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system. Journal of Veterinary Medical Science, 83(1), 1-8.

Morato, X., Cunha, R. A., & Ciruela, F. (2019). G protein-coupled receptor 37 (GPR37) emerges as an important modulator of adenosinergic transmission in the striatum. Neural Regeneration Research, 14(11), 1912.

Jolly, S., Bazargani, N., Quiroga, A. C., Pringle, N. P., Attwell, D., Richardson, W. D., & Li, H. (2018). G protein‐coupled receptor 37‐like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia. Glia, 66(1), 47-61.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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