GPSM1

G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001 [PubMed 11278352]).[supplied by OMIM

Full Name

G-protein signaling modulator 1 (AGS3-like, C. elegans)

Function

Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.

Biological Process

Cell differentiation Source: UniProtKB-KW
Negative regulation of GTPase activity Source: UniProtKB
Negative regulation of guanyl-nucleotide exchange factor activity Source: UniProtKB
Nervous system development Source: UniProtKB-KW
Positive regulation of macroautophagy Source: UniProtKB

Cellular Location

Endoplasmic reticulum membrane; Golgi apparatus membrane; Cell membrane; Cytosol

PTM

Phosphorylation regulates interaction with G(i/o) alpha.