Mouse Anti-GPSM1 Recombinant Antibody (CBLG1-209) (CBMAB-G0735-LY)

This product is antibody recognizes GPSM1. The antibody CBLG1-209 immunoassay techniques such as: ELISA, WB.
See all GPSM1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBLG1-209

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

G-protein signaling modulator 1 (AGS3-like, C. elegans)

Introduction

G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Entrez Gene ID

26086

UniProt ID

Q86YR5

Alternative Names

G Protein Signaling Modulator 1; G-Protein Signalling Modulator 1 (AGS3-Like; C. Elegans); Activator Of G-Protein Signaling 3; AGS3; G-Protein Signaling Modulator 1; G-Protein-Signaling Modulator 1; AGS3 Homolog (C. Elegans);

Function

Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.

Biological Process

Cell differentiation Source: UniProtKB-KW
Negative regulation of GTPase activity Source: UniProtKB
Negative regulation of guanyl-nucleotide exchange factor activity Source: UniProtKB
Nervous system development Source: UniProtKB-KW
Positive regulation of macroautophagy Source: UniProtKB

Cellular Location

Endoplasmic reticulum membrane; Golgi apparatus membrane; Cell membrane; Cytosol

PTM

Phosphorylation regulates interaction with G(i/o) alpha.

References

Yan, J., Zhang, Y., Yu, H., Zong, Y., Wang, D., Zheng, J., ... & Hu, C. (2022). GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages. Nature Communications, 13(1), 7260.

Zhang, Y., Zhou, B., Sun, J., He, Q., & Zhao, Y. (2021). Knockdown of GPSM1 Inhibits the Proliferation and Promotes the Apoptosis of B-Cell Acute Lymphoblastic Leukemia Cells by Suppressing the ADCY6-RAPGEF3-JNK Signaling Pathway. Pathology & Oncology Research, 27, 643376.

Cai, X., Fu, H., Wang, Y., Liu, Q., & Wang, X. (2020). Depletion of GPSM1 enhances ovarian granulosa cell apoptosis via cAMP-PKA-CREB pathway in vitro. Journal of Ovarian Research, 13, 1-10.

Ding, Q., Tan, A. L. M., Parra, E. J., Cruz, M., Sim, X., Teo, Y. Y., ... & Chen, H. (2020). Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function. Journal of human genetics, 65(4), 411-420.

Cai, X., Fu, H., Wang, Y., Liu, Q., & Wang, X. (2020). Whole-exome sequencing identifies GPSM1 as a susceptibility gene for premature ovarian insufficiency.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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