GSC
This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]
Full Name
Goosecoid Homeobox
Function
Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity).
Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals.
Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals.
Biological Process
Dorsal/ventral neural tube patterning Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Forebrain development Source: Ensembl
Gastrulation Source: UniProtKB
Middle ear morphogenesis Source: UniProtKB
Muscle organ morphogenesis Source: Ensembl
Negative regulation of Wnt signaling pathway Source: Ensembl
Neural crest cell fate specification Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction involved in regulation of gene expression Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Forebrain development Source: Ensembl
Gastrulation Source: UniProtKB
Middle ear morphogenesis Source: UniProtKB
Muscle organ morphogenesis Source: Ensembl
Negative regulation of Wnt signaling pathway Source: Ensembl
Neural crest cell fate specification Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction involved in regulation of gene expression Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Short stature, auditory canal atresia, mandibular hypoplasia, skeletal abnormalities (SAMS):
An autosomal recessive developmental disorder with features of a first and second branchial arch syndrome, and with unique rhizomelic skeletal anomalies. Craniofacial abnormalities can lead to conductive hearing loss, respiratory insufficiency, and feeding difficulties. Skeletal features include bilateral humeral hypoplasia, humeroscapular synostosis, pelvic abnormalities, and proximal defects of the femora. Affected individuals may also have some features of a neurocristopathy or abnormal mesoderm development, such as urogenital anomalies, that are distinct from other branchial arch syndromes.
An autosomal recessive developmental disorder with features of a first and second branchial arch syndrome, and with unique rhizomelic skeletal anomalies. Craniofacial abnormalities can lead to conductive hearing loss, respiratory insufficiency, and feeding difficulties. Skeletal features include bilateral humeral hypoplasia, humeroscapular synostosis, pelvic abnormalities, and proximal defects of the femora. Affected individuals may also have some features of a neurocristopathy or abnormal mesoderm development, such as urogenital anomalies, that are distinct from other branchial arch syndromes.
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Anti-GSC antibodies
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CompareTarget: GSC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3515
Application*: IH, F
Target: GSC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3727
Application*: WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1824
Application*: E, WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-1823
Application*: SE, E, WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2982
Application*: WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2981
Application*: WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4F11
Application*: IF, WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C5D5
Application*: E, F
Target: GSC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C5D10
Application*: E, WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-86123
Application*: E, IF, WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3D11
Application*: E, WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2C1
Application*: E, WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D7
Application*: F
Target: GSC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1C2
Application*: E, IH, WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14i161
Application*: E, WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14i160
Application*: E, F
Target: GSC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0502
Application*: E, EC, WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0501
Application*: E, P, WB
Target: GSC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-0500
Application*: E, P, WB
Target: GSC
Host: Mouse
Specificity: Human
Clone: CBFYH-2853
Application*: E, F, IH, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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