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Mouse Anti-GSC Recombinant Antibody (CBT3727) (V2LY-0625-LY2855)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3727
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of human GSC (AA: 191-257) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Goosecoid Homeobox
Entrez Gene ID
145258
UniProt ID
P56915
Function
Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity).

Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals.
Biological Process
Dorsal/ventral neural tube patterning Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Forebrain development Source: Ensembl
Gastrulation Source: UniProtKB
Middle ear morphogenesis Source: UniProtKB
Muscle organ morphogenesis Source: Ensembl
Negative regulation of Wnt signaling pathway Source: Ensembl
Neural crest cell fate specification Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction involved in regulation of gene expression Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Short stature, auditory canal atresia, mandibular hypoplasia, skeletal abnormalities (SAMS):
An autosomal recessive developmental disorder with features of a first and second branchial arch syndrome, and with unique rhizomelic skeletal anomalies. Craniofacial abnormalities can lead to conductive hearing loss, respiratory insufficiency, and feeding difficulties. Skeletal features include bilateral humeral hypoplasia, humeroscapular synostosis, pelvic abnormalities, and proximal defects of the femora. Affected individuals may also have some features of a neurocristopathy or abnormal mesoderm development, such as urogenital anomalies, that are distinct from other branchial arch syndromes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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