GSPT1

Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1.

G1 to S phase transition 1

Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity).

Stimulates the activity of ETF1 (By similarity).

Involved in regulation of mammalian cell growth (PubMed:2511002).

Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019).

Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).

Cytoplasmic translational termination Source: GO_Central
G1/S transition of mitotic cell cycle Source: UniProtKB
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
Protein methylation Source: MGI
Regulation of translational termination Source: UniProtKB
Translation Source: GO_Central
Translational termination Source: ComplexPortal

Cytosol; Translation release factor complex