Rabbit Anti-GSPT1 Recombinant Antibody (EG1460) (V2LY-0226-LY1691)

Sellar, R. S., Sperling, A. S., Słabicki, M., Gasser, J. A., McConkey, M. E., Donovan, K. A., ... & Ebert, B. L. (2022). Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells. The Journal of Clinical Investigation, 132(16).

Hansen, J. D., Correa, M., Alexander, M., Nagy, M., Huang, D., Sapienza, J., ... & Lopez-Girona, A. (2021). CC-90009: a cereblon E3 ligase modulating drug that promotes selective degradation of GSPT1 for the treatment of acute myeloid leukemia. Journal of Medicinal Chemistry, 64(4), 1835-1843.

Nishiguchi, G., Keramatnia, F., Min, J., Chang, Y., Jonchere, B., Das, S., ... & Rankovic, Z. (2021). Identification of potent, selective, and orally bioavailable small-molecule GSPT1/2 degraders from a focused library of cereblon modulators. Journal of Medicinal Chemistry, 64(11), 7296-7311.

Li, Z., Xie, X., Fan, X., & Li, X. (2020). Long non-coding RNA MINCR regulates miR-876-5p/GSPT1 axis to aggravate glioma progression. Neurochemical Research, 45(7), 1690-1699.

Powell, C. E., Du, G., Che, J., He, Z., Donovan, K. A., Yue, H., ... & Gray, N. S. (2020). Selective degradation of GSPT1 by cereblon modulators identified via a focused combinatorial library. ACS chemical biology, 15(10), 2722-2730.

Uy, G. L., Minden, M. D., Montesinos, P., DeAngelo, D. J., Altman, J. K., Koprivnikar, J., ... & Zeidan, A. M. (2019). Clinical activity of CC-90009, a cereblon E3 ligase modulator and first-in-class GSPT1 degrader, as a single agent in patients with relapsed or refractory acute myeloid leukemia (R/R AML): first results from a Phase I dose-finding study. Blood, 134, 232.

Ishoey, M., Chorn, S., Singh, N., Jaeger, M. G., Brand, M., Paulk, J., ... & Winter, G. E. (2018). Translation termination factor GSPT1 is a phenotypically relevant off-target of heterobifunctional phthalimide degraders. ACS Chemical Biology, 13(3), 553-560.

Tian, Q. G., Tian, R. C., Liu, Y., Niu, A. Y., Zhang, J., & Gao, W. F. (2018). The role of miR-144/GSPT1 axis in gastric cancer. Eur Rev Med Pharmacol Sci, 22(13), 4138-4145.

Hansen, J. D., Condroski, K., Correa, M., Muller, G., Man, H. W., Ruchelman, A., ... & Lu, C. C. (2018). Protein degradation via CRL4CRBN ubiquitin ligase: discovery and structure–activity relationships of novel glutarimide analogs that promote degradation of aiolos and/or GSPT1. Journal of Medicinal Chemistry, 61(2), 492-503.

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols