GSR

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
Full Name
glutathione reductase
Function
Maintains high levels of reduced glutathione in the cytosol.
Biological Process
Cell redox homeostasis Source: GO_Central
Cellular response to oxidative stress Source: GO_Central
Glutathione metabolic process Source: GO_Central
Cellular Location
Isoform Mitochondrial: Mitochondrion
Isoform Cytoplasmic: Cytoplasm
Involvement in disease
Hemolytic anemia due to glutathione reductase deficiency (HAGRD):
An autosomal recessive disease characterized by hemolytic anemia and impaired activity of glutathione reductase. Patients experience hemolytic anemia in response to oxidative stress or ingestion of fava beans.
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Anti-GSR antibodies

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Mouse Anti-GSR Recombinant Antibody (11D10) (CBMAB-G0872-LY)

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Target: GSR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 11D10
Application*: WB
Datasheet SDS

Mouse Anti-GSR Recombinant Antibody (CBLG1-1933) (CBMAB-G5326-LY)

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Target: GSR
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-1933
Application*: WB
Datasheet SDS

Mouse Anti-GSR Recombinant Antibody (CBLG1-1932) (CBMAB-G5325-LY)

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Target: GSR
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1932
Application*: WB
Datasheet SDS

Mouse Anti-GSR Recombinant Antibody (CBLG1-1927) (CBMAB-G5320-LY)

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Target: GSR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-1927
Application*: E, IP
Datasheet SDS

Mouse Anti-GSR Recombinant Antibody (CBLG1-1926) (CBMAB-G5319-LY)

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Target: GSR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-1926
Application*: E, IP
Datasheet SDS

Mouse Anti-GSR Recombinant Antibody (CBLG1-1925) (CBMAB-G5318-LY)

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Target: GSR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-1925
Application*: WB
Datasheet SDS

Rabbit Anti-GSR Recombinant Antibody (CBLG1-3000) (CBMAB-G5317-LY)

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Target: GSR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLG1-3000
Application*: WB
Datasheet SDS

Rat Anti-GSR Recombinant Antibody (AP-MAB0866) (CBMAB-G5314-LY)

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Target: GSR
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: AP-MAB0866
Application*: P, C, F
Datasheet SDS

Mouse Anti-GSR Recombinant Antibody (6B4) (CBMAB-G5313-LY)

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Target: GSR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6B4
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-GSR Recombinant Antibody (1A7) (CBMAB-G5310-LY)

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Target: GSR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1A7
Application*: IF(IC), IP
Datasheet SDS

Mouse Anti-GSR Recombinant Antibody (16C54) (CBMAB-G5309-LY)

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Target: GSR
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16C54
Application*: E, WB
Datasheet SDS

Mouse Anti-GSR Recombinant Antibody (10K216) (CBMAB-G5307-LY)

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Target: GSR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 10K216
Application*: E, IP
Datasheet SDS

Mouse Anti-GSR Recombinant Antibody (10K215) (CBMAB-G5306-LY)

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Target: GSR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 10K215
Application*: E, IP
Datasheet SDS

Mouse Anti-GSR Recombinant Antibody (AT11D10) (CBMAB-H1384-FY)

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Target: GSR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: AT11D10
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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