GYPB

Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants.

Full Name

Glycophorin B (Mns Blood Group)

Function

This protein is a minor sialoglycoprotein in erythrocyte membranes.

Cellular Location

Cell membrane

Topology

Extracellular: 20-59
Helical: 60-81
Cytoplasmic: 82-91

PTM

The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.