GZMA

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.
Full Name
granzyme A
Function
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3257574, PubMed:3262682, PubMed:3263427, PubMed:32299851, PubMed:12819770).

It cleaves after Lys or Arg (PubMed:32299851, PubMed:12819770).

Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death (PubMed:32299851).

Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity (PubMed:12524539).

Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (PubMed:11555662, PubMed:12628186, PubMed:16818237).
Biological Process
Apoptotic process Source: UniProtKB
Cytolysis Source: UniProtKB-KW
Cytotoxic T cell pyroptotic process Source: UniProtKB
Granzyme-mediated programmed cell death signaling pathway Source: UniProtKB
Immune response Source: UniProtKB
Negative regulation of DNA binding Source: UniProtKB
Negative regulation of endodeoxyribonuclease activity Source: UniProtKB
Negative regulation of oxidoreductase activity Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Proteolysis involved in cellular protein catabolic process Source: UniProtKB
Pyroptosis Source: UniProtKB
Response to bacterium Source: Ensembl
Cellular Location
Isoform alpha: Secreted; Cytoplasmic granule. Delivered into the target cell by perforin.
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Anti-GZMA antibodies

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Mouse Anti-GZMA Recombinant Antibody (CBLG1-2197) (CBMAB-G5901-LY)

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Target: GZMA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-2197
Application*: SE, E
Datasheet SDS

Mouse Anti-GZMA Recombinant Antibody (GzA-3G8.5) (CBMAB-G0984-LY)

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Target: GZMA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: GzA-3G8.5
Application*: F
Datasheet SDS

Rabbit Anti-GZMA Recombinant Antibody (EG1425) (CBMAB-EN1704-LY)

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Target: GZMA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1425
Application*: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:5000
Datasheet SDS

Mouse Anti-GZMA Recombinant Antibody (CBLG1-2204) (CBMAB-G5908-LY)

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Target: GZMA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2204
Application*: E, IH, IP
Datasheet SDS

Mouse Anti-GZMA Recombinant Antibody (CBLG1-2201) (CBMAB-G5905-LY)

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Target: GZMA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2201
Application*: P, WB
Datasheet SDS

Mouse Anti-GZMA Recombinant Antibody (CBLG1-2200) (CBMAB-G5904-LY)

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Target: GZMA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2200
Application*: E, WB
Datasheet SDS

Mouse Anti-GZMA Recombinant Antibody (CBLG1-2199) (CBMAB-G5903-LY)

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Target: GZMA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2199
Application*: E, IH, IP
Datasheet SDS

Mouse Anti-GZMA Recombinant Antibody (CBLG1-2198) (CBMAB-G5902-LY)

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Target: GZMA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-2198
Application*: E, EC
Datasheet SDS

Mouse Anti-GZMA Recombinant Antibody (7H129) (CBMAB-G5899-LY)

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Target: GZMA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H129
Application*: E, WB
Datasheet SDS

Mouse Anti-GZMA Recombinant Antibody (CBLG1-292) (CBMAB-G0986-LY)

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Target: GZMA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-292
Application*: IH, WB
Datasheet SDS

Human Anti-GZMA Recombinant Antibody (REA162) (CBMAB-G0985-LY)

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Target: GZMA
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: REA162
Application*: F
Datasheet SDS

Mouse Anti-GZMA Recombinant Antibody (3G8.5) (CBMAB-G0976-LY)

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Target: GZMA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 3G8.5
Application*: F
Datasheet SDS

Mouse Anti-GZMA Recombinant Antibody (356412) (CBMAB-G0975-LY)

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Target: GZMA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 356412
Application*: IP, F
Datasheet SDS

Mouse Anti-GZMA (AA 26-2622) Recombinant Antibody (CBFYH-0556) (CBMAB-H1438-FY)

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Target: GZMA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0556
Application*: F
Datasheet SDS

Mouse Anti-GZMA (AA 22-262) Recombinant Antibody (CBFYH-0555) (CBMAB-H1437-FY)

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Target: GZMA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0555
Application*: E, IH, IP
Datasheet SDS

Human Anti-GZMA Recombinant Antibody (CBFYH-0553) (CBMAB-H1435-FY)

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Target: GZMA
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0553
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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