HOXB8

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.

Full Name

HOMEOBOX B8

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Adult locomotory behavior Source: Ensembl
Anterior/posterior pattern specification Source: Ensembl
Dorsal spinal cord development Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Grooming behavior Source: Ensembl
Negative regulation of myeloid cell differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Sensory perception of pain Source: Ensembl

Cellular Location

Nucleus