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Mouse Anti-HOXB8 (AA 16-114) Recombinant Antibody (CBFYH-1781) (CBMAB-H2791-FY)

This product is mouse antibody that recognizes HOXB8. The antibody CBFYH-1781 can be used for immunoassay techniques such as: ELISA, WB.
See all HOXB8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1781
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: GESLRPNYYD CGFAQDLGGR PTVVYGPSSG GSFQHPSQIQ EFYHGPSSLS TAPYQQNPCA VACHGDPGNF YGYDPLQRQS LFGAQDPDLV QYADCKLAA
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 16-114

Target

Full Name
HOMEOBOX B8
Introduction
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.
Entrez Gene ID
3218
UniProt ID
P17481
Alternative Names
Homeobox B8; Homeobox Protein Hox-2.4; Homeobox Protein Hox-2D; Homeo Box B8; HOX2D; Homeobox Protein Hox-B8; Homeo Box 2D; Hox-2.4; HOX2
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Adult locomotory behavior Source: Ensembl
Anterior/posterior pattern specification Source: Ensembl
Dorsal spinal cord development Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Grooming behavior Source: Ensembl
Negative regulation of myeloid cell differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Sensory perception of pain Source: Ensembl
Cellular Location
Nucleus

Li, X., Lan, Q., Lai, W., Wu, H., Xu, H., Fang, K., ... & Zeng, Y. (2022). Exosome-derived lnc-HOXB8-1: 2 induces tumor-associated macrophage infiltration to promote neuroendocrine differentiated colorectal cancer progression by sponging hsa-miR-6825-5p. BMC cancer, 22(1), 1-17.

Van Deren, D. A., De, S., Xu, B., Eschenbacher, K. M., Zhang, S., & Capecchi, M. R. (2022). Defining the Hoxb8 cell lineage during murine definitive hematopoiesis. Development, 149(8), dev200200.

Lu, N., Yin, Y., Yao, Y., & Zhang, P. (2021). SNHG3/miR‐2682‐5p/HOXB8 promotes cell proliferation and migration in oral squamous cell carcinoma. Oral Diseases, 27(5), 1161-1170.

Huang, T., Cai, M., Chen, C., Ling, C., Zhang, B., Zheng, W., & Luo, L. (2021). LINC01116 boosts the progression of pituitary adenoma via regulating miR-744–5p/HOXB8 pathway. Molecular and Cellular Endocrinology, 536, 111350.

Ying, Y., Wang, Y., Huang, X., Sun, Y., Zhang, J., Li, M., ... & Shu, X. S. (2020). Oncogenic HOXB8 is driven by MYC-regulated super-enhancer and potentiates colorectal cancer invasiveness via BACH1. Oncogene, 39(5), 1004-1017.

Wang, T., Lin, F., Sun, X., Jiang, L., Mao, R., Zhou, S., ... & Li, S. (2019). HOXB8 enhances the proliferation and metastasis of colorectal cancer cells by promoting EMT via STAT3 activation. Cancer Cell International, 19(1), 1-12.

Zhang, L., Wang, Y., Zhang, L., You, G., Li, C., Meng, B., ... & Zhang, M. (2019). LINC01006 promotes cell proliferation and metastasis in pancreatic cancer via miR-2682-5p/HOXB8 axis. Cancer cell international, 19(1), 1-12.

Ding, J., Wu, W., Yang, J., & Wu, M. (2019). Long non-coding RNA MIF-AS1 promotes breast cancer cell proliferation, migration and EMT process through regulating miR-1249-3p/HOXB8 axis. Pathology-Research and Practice, 215(7), 152376.

Liu, Y. J., Zhou, H. G., Chen, L. H., Qu, D. C., Wang, C. J., Xia, Z. Y., & Zheng, J. H. (2019). MiR-32-5p regulates the proliferation and metastasis of cervical cancer cells by targeting HOXB8. European Review for Medical & Pharmacological Sciences, 23(1).

Nagarajan, N., Jones, B. W., West, P. J., Marc, R. E., & Capecchi, M. (2018). Corticostriatal circuit defects in Hoxb8 mutant mice. Molecular psychiatry, 23(9), 1868-1877.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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