HTR4

This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
Full Name
5-hydroxytryptamine receptor 4
Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Biological Process
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Regulation of appetite Source: InterPro
Cellular Location
Cell membrane; Endosome. Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.
Topology
Extracellular: 1-19
Helical: 20-40
Cytoplasmic: 41-58
Helical: 59-79
Extracellular: 80-93
Helical: 94-116
Cytoplasmic: 117-137
Helical: 138-158
Extracellular: 159-192
Helical: 193-213
Cytoplasmic: 214-260
Helical: 261-281
Extracellular: 282-294
Helical: 295-315
Cytoplasmic: 316-388
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Anti-HTR4 antibodies

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Mouse Anti-HTR4 Recombinant Antibody (CBXS-2407) (CBMAB-S5164-CQ)

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Target: HTR4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-2407
Application*: IH
Datasheet SDS

Rabbit Anti-HTR4 Recombinant Antibody (D8O5K) (CBMAB-CP2395-LY)

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Target: HTR4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D8O5K
Application*: WB
Datasheet SDS

Rabbit Anti-HTR4 Recombinant Antibody (CBXS-5446) (CBMAB-S2656-CQ)

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Target: HTR4
Host: Rabbit
Specificity: Human, Mouse, Rat
Clone: CBXS-5446
Application*: WB
Datasheet SDS

Rabbit Anti-HTR4 Recombinant Antibody (EG1592) (CBMAB-EN1905-LY)

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Target: HTR4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1592
Application*: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:5000
Datasheet SDS

Mouse Anti-HTR4 Recombinant Antibody (CBLQH-001) (CBMAB-2051CQ)

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Target: HTR4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLQH-001
Application*: IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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