Sign in or Register   Sign in or Register
  |  

Rabbit Anti-HTR4 Recombinant Antibody (D8O5K) (CBMAB-CP2395-LY)

The product is antibody recognizes HTR4. The antibody D8O5K immunoassay techniques such as: WB.
See all HTR4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D8O5K
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala361 of human 5-HTR4 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
5-hydroxytryptamine receptor 4
Introduction
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
Entrez Gene ID
Human3360
Mouse15562
Rat25324
UniProt ID
HumanQ13639
MouseP97288
RatQ62758
Alternative Names
5-HT4; 5-HT4R
Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Biological Process
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Regulation of appetite Source: InterPro
Cellular Location
Cell membrane; Endosome. Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.
Topology
Extracellular: 1-19
Helical: 20-40
Cytoplasmic: 41-58
Helical: 59-79
Extracellular: 80-93
Helical: 94-116
Cytoplasmic: 117-137
Helical: 138-158
Extracellular: 159-192
Helical: 193-213
Cytoplasmic: 214-260
Helical: 261-281
Extracellular: 282-294
Helical: 295-315
Cytoplasmic: 316-388
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-HTR4 Recombinant Antibody (D8O5K)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare