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Rabbit Anti-HTR4 Recombinant Antibody (D8O5K) (CBMAB-CP2395-LY)

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Datasheet
SDS
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Basic Information

Host Animal
Rabbit
Clone
D8O5K
Application
WB
Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala361 of human 5-HTR4 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
5-hydroxytryptamine receptor 4
Introduction
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
Entrez Gene ID
Human3360
Mouse15562
Rat25324
UniProt ID
HumanQ13639
MouseP97288
RatQ62758
Alternative Names
5-HT4; 5-HT4R
Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Biological Process
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Regulation of appetite Source: InterPro
Cellular Location
Cell membrane; Endosome. Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.
Topology
Extracellular: 1-19
Helical: 20-40
Cytoplasmic: 41-58
Helical: 59-79
Extracellular: 80-93
Helical: 94-116
Cytoplasmic: 117-137
Helical: 138-158
Extracellular: 159-192
Helical: 193-213
Cytoplasmic: 214-260
Helical: 261-281
Extracellular: 282-294
Helical: 295-315
Cytoplasmic: 316-388
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-HTR4 Recombinant Antibody (CBXS-2407) (CAT#: CBMAB-S5164-CQ)

Mouse Anti-HTR4 Recombinant Antibody (CBLQH-001) (CAT#: CBMAB-2051CQ)

Rabbit Anti-HTR4 Recombinant Antibody (EG1592) (CAT#: CBMAB-EN1905-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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