HYOU1
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Full Name
Hypoxia Up-Regulated 1
Function
Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
Biological Process
Cellular response to hypoxia Source: ParkinsonsUK-UCL
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: ParkinsonsUK-UCL
Negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway Source: Ensembl
Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Response to ischemia Source: ParkinsonsUK-UCL
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: ParkinsonsUK-UCL
Negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway Source: Ensembl
Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Response to ischemia Source: ParkinsonsUK-UCL
Cellular Location
Endoplasmic reticulum lumen
Involvement in disease
Immunodeficiency 59 and hypoglycemia (IMD59):
An autosomal recessive primary immunologic disorder characterized by combined immunodeficiency, granulocytopenia, B-cell and dendritic cell deficiency, recurrent septic infections of the respiratory tract, skin and mucous membranes, and disturbed glucose metabolism.
An autosomal recessive primary immunologic disorder characterized by combined immunodeficiency, granulocytopenia, B-cell and dendritic cell deficiency, recurrent septic infections of the respiratory tract, skin and mucous membranes, and disturbed glucose metabolism.
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Anti-HYOU1 antibodies
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CompareTarget: HYOU1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6F7
Application*: WB, E
Target: HYOU1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-2578
Application*: E, WB
Target: HYOU1
Host: Rabbit
Specificity: Human
Clone: CBFYH-2577
Application*: F, P, WB
Target: HYOU1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2574
Application*: E, P, WB
Target: HYOU1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYH-2573
Application*: IH, WB, IP
Target: HYOU1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2575
Application*: E, P, WB
Target: HYOU1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 201
Application*: E, P
Target: HYOU1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 6E3-2C3
Application*: WB, IF
Target: HYOU1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6G7-2H5
Application*: WB, IF
Target: HYOU1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0013
Application*: WB, P, F
Target: HYOU1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXO-0449
Application*: E
Target: HYOU1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 695-994
Tag: His Tag
Target: HYOU1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0063
Application*: IP, IF, WB, F, P
Target: HYOU1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: BA0297
Application*: WB, P, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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