Mouse Anti-HYOU1 Recombinant Antibody (CBXO-0449) (CBMAB-O0178-CQ)

Name: Mouse Anti-HYOU1 Recombinant Antibody (CBXO-0449)
SKU: CBMAB-O0178-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXO-0449

Application

ELISA

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Hypoxia Up-Regulated 1

Introduction

The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

10525

UniProt ID

Q9Y4L1

Alternative Names

Hypoxia Up-Regulated 1; 170 KDa Glucose-Regulated Protein; 150 KDa Oxygen-Regulated Protein; GRP-170; ORP-150; Grp170

Function

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.

Biological Process

Cellular response to hypoxia Source: ParkinsonsUK-UCL
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: ParkinsonsUK-UCL
Negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway Source: Ensembl
Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Response to ischemia Source: ParkinsonsUK-UCL

Cellular Location

Endoplasmic reticulum lumen

Involvement in disease

Immunodeficiency 59 and hypoglycemia (IMD59):
An autosomal recessive primary immunologic disorder characterized by combined immunodeficiency, granulocytopenia, B-cell and dendritic cell deficiency, recurrent septic infections of the respiratory tract, skin and mucous membranes, and disturbed glucose metabolism.

Wang, Z., Tan, C., Duan, C., Wu, J., Zhou, D., Hou, L., ... & Hou, X. (2023). FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response. Redox Biology, 60, 102618.

Wang, W., Jiang, X., Xia, F., Chen, X., Li, G., Liu, L., ... & Chen, C. (2023). HYOU1 promotes cell proliferation, migration, and invasion via the PI3K/AKT/FOXO1 feedback loop in bladder cancer. Molecular Biology Reports, 50(1), 453-464.

Pan, P. K., Wang, K. T., Nan, F. H., Wu, T. M., & Wu, Y. S. (2022). Red Algae “Sarcodia suieae” Acetyl-Xylogalactan Downregulate Heat-Induced Macrophage Stress Factors Ddit3 and Hyou1 Compared to the Aquatic Animal Model of Nile Tilapia (Oreochromis niloticus) Brain Arachidonic Acid Expression. International Journal of Molecular Sciences, 23(23), 14662.

Arab, F., Rezaei, N., Taheri, F., Kouhpeikar, H., Rayzan, E., Mirbeyk, M., ... & Ghadami, M. (2022). The Clinical and Molecular Assessment of Iranian Families with Severe Congenital Neutropenia, Identification of HYOU1 and SHOC2 as Potential Novel Gene Defects. Iranian Journal of Allergy, Asthma and Immunology, 21(3), 344-354.

Hao, A., Wang, Y., Zhang, X., Li, J., Li, Y., Li, D., ... & Sui, G. (2021). Long non-coding antisense RNA HYOU1-AS is essential to human breast cancer development through competitive binding hnRNPA1 to promote HYOU1 expression. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1868(4), 118951.

Rao, S., Oyang, L., Liang, J., Yi, P., Han, Y., Luo, X., ... & Liao, Q. (2021). Biological function of HYOU1 in tumors and other diseases. OncoTargets and therapy, 1727-1735.

Liu, J., & Wang, Y. (2021). Long non-coding RNA KCNQ1OT1 facilitates the progression of cervical cancer and tumor growth through modulating miR-296-5p/HYOU1 axis. Bioengineered, 12(1), 8753-8767.

Wang, J. M., Jiang, J. Y., Zhang, D. L., Du, X., Wu, T., & Du, Z. X. (2021). HYOU1 facilitates proliferation, invasion and glycolysis of papillary thyroid cancer via stabilizing LDHB mRNA. Journal of Cellular and Molecular Medicine, 25(10), 4814-4825.

Lee, M., Song, Y., Choi, I., Lee, S. Y., Kim, S., Kim, S. H., ... & Seo, H. R. (2021). Expression of HYOU1 via reciprocal crosstalk between NSCLC Cells and HUVECs control cancer progression and chemoresistance in tumor spheroids. Molecules and Cells, 44(1), 50.

Li, X., Zhang, N. X., Ye, H. Y., Song, P. P., Chang, W., Chen, L., ... & Wang, N. N. (2019). HYOU1 promotes cell growth and metastasis via activating PI3K/AKT signaling in epithelial ovarian cancer and predicts poor prognosis. European Review for Medical & Pharmacological Sciences, 23(10).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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