ID1

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

ID1

Function

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Biological Process

Angiogenesis Source: BHF-UCL
Blood vessel endothelial cell migration Source: BHF-UCL
Blood vessel morphogenesis Source: BHF-UCL
Brain development Source: Ensembl
Cell-abiotic substrate adhesion Source: Ensembl
Cell differentiation Source: GO_Central
Cellular response to dopamine Source: Ensembl
Cellular response to epidermal growth factor stimulus Source: Ensembl
Cellular response to nerve growth factor stimulus Source: Ensembl
Cellular response to peptide Source: Ensembl
Circadian regulation of gene expression Source: GO_Central
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Negative regulation of dendrite morphogenesis Source: Ensembl
Negative regulation of DNA binding Source: Ensembl
Negative regulation of DNA-binding transcription factor activity Source: ARUK-UCL
Negative regulation of endothelial cell differentiation Source: Ensembl
Negative regulation of protein binding Source: Ensembl
Negative regulation of transcription, DNA-templated Source: GDB
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Negative regulation of transcription by transcription factor localization Source: BHF-UCL
Neuron differentiation Source: Ensembl
Positive regulation of actin filament bundle assembly Source: Ensembl
Positive regulation of epithelial cell proliferation Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Regulation of vasculature development Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: BHF-UCL

Cellular Location

Cytoplasm; Nucleus