IFI27

IFI27 (Interferon Alpha Inducible Protein 27) is a Protein Coding gene. Diseases associated with IFI27 include Lung Clear Cell Carcinoma and Clear Cell Adenocarcinoma Of The Ovary. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include RNA polymerase II activating transcription factor binding and lamin binding. An important paralog of this gene is IFI27L2.

Full Name

interferon, alpha-inducible protein 27

Function

Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766).

Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806).

Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746).

Also functions in TNFSF10-induced apoptosis (PubMed:24970806).

May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340).

May thereby play a role in the vascular response to injury (By similarity).

In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077).

May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077).

Biological Process

Apoptotic process Source: UniProtKB
Apoptotic signaling pathway Source: GO_Central
Defense response to virus Source: UniProtKB
Extrinsic apoptotic signaling pathway Source: UniProtKB
Innate immune response Source: UniProtKB
Modulation by host of viral genome replication Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: MGI
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Protein K48-linked ubiquitination Source: UniProtKB
Regulation of protein export from nucleus Source: MGI
Type I interferon signaling pathway Source: UniProtKB

Cellular Location

Mitochondrion membrane; Nucleus inner membrane; Endoplasmic reticulum membrane. Exclusive localizations in either the nucleus or the mitochondrion have been reported.