Mouse Anti-IFI27 Recombinant Antibody (CBYY-I0470) (CBMAB-I1105-YY)

This product is Mouse antibody that recognizes IFI27 . The antibody CBYY-I0470 can be used for immunoassay techniques such as: IHC-Fr, IHC-P
See all IFI27 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-I0470

Antibody Isotype

IgG1, κ

Application

IHC-Fr, IHC-P

Basic Information

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA buffer, pH 7.5

Preservative

sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

interferon, alpha-inducible protein 27

Introduction

IFI27 (Interferon Alpha Inducible Protein 27) is a Protein Coding gene. Diseases associated with IFI27 include Lung Clear Cell Carcinoma and Clear Cell Adenocarcinoma Of The Ovary. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System.

Entrez Gene ID

3429

UniProt ID

P40305

Alternative Names

Interferon Alpha Inducible Protein 27

Function

Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766).

Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806).

Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746).

Also functions in TNFSF10-induced apoptosis (PubMed:24970806).

May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340).

May thereby play a role in the vascular response to injury (By similarity).

In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077).

May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077).

Biological Process

Apoptotic process Source: UniProtKB
Apoptotic signaling pathway Source: GO_Central
Defense response to virus Source: UniProtKB
Extrinsic apoptotic signaling pathway Source: UniProtKB
Innate immune response Source: UniProtKB
Modulation by host of viral genome replication Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: MGI
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Protein K48-linked ubiquitination Source: UniProtKB
Regulation of protein export from nucleus Source: MGI
Type I interferon signaling pathway Source: UniProtKB

Cellular Location

Mitochondrion membrane; Nucleus inner membrane; Endoplasmic reticulum membrane. Exclusive localizations in either the nucleus or the mitochondrion have been reported.

References

Shojaei, M., Shamshirian, A., Monkman, J., Grice, L., Tran, M., Tan, C. W., ... & Tang, B. (2023). IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study. Frontiers in Immunology, 13, 1060438.

Palm, A. A., Veerla, S., Lindman, J., Isberg, P. E., Johansson, E., Biague, A., ... & Jansson, M. (2022). Interferon alpha-inducible protein 27 expression is linked to disease severity in chronic infection of both HIV-1 and HIV-2. Frontiers in Virology, 2, 929053.

Huang, H., Lv, J., Huang, Y., Mo, Z., Xu, H., Huang, Y., ... & Qin, Y. (2022). IFI27 is a potential therapeutic target for HIV infection. Annals of Medicine, 54(1), 314-325.

Huang, S., Zhao, J., Song, J., Li, Y., Zuo, R., Sa, Y., ... & OuYang, H. (2021). Interferon alpha-inducible protein 27 (IFI27) is a prognostic marker for pancreatic cancer based on comprehensive bioinformatics analysis. Bioengineered, 12(1), 8515-8528.

Ullah, H., Sajid, M., Yan, K., Feng, J., He, M., Shereen, M. A., ... & Zhou, L. (2021). Antiviral activity of interferon alpha-inducible protein 27 against hepatitis B virus gene expression and replication. Frontiers in Microbiology, 12, 656353.

Min, Z., Ye, Z., Gang, L., Boyu, D., & Xueyan, X. (2020). IFI27 as a potential indicator for severe Enterovirus 71-infected hand foot and mouth disease. Virus research, 289, 198149.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-IFI27 Recombinant Antibody (CBYY-I0894)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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