IFNL2

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Full Name
Interferon Lambda 2
Function
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Biological Process
Defense response to virus Source: UniProtKB
Innate immune response Source: GO_Central
Mucosal immune response Source: UniProtKB
Positive regulation of immune response Source: InterPro
Receptor signaling pathway via JAK-STAT Source: InterPro
Cellular Location
Secreted
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Anti-IFNL2 antibodies

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Mouse Anti-IFNL2 Recombinant Antibody (CBT4746) (V2LY-0625-LY466)

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Target: IFNL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4746
Application*: WB, IH
Datasheet SDS

Mouse Anti-IFNL2 Recombinant Antibody (CBT2644) (V2LY-0625-LY464)

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Target: IFNL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2644
Application*: IC
Datasheet SDS

Mouse Anti-IFNL2 Recombinant Antibody (A542) (CBMAB-AP10867LY)

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Target: IFNL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A542
Application*: ELISA, IHC, WB
Datasheet SDS

Mouse Anti-IFNL2 Recombinant Antibody (A422) (CBMAB-AP3967LY)

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Target: IFNL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A422
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-IFNL2 Recombinant Antibody (A421) (CBMAB-AP3955LY)

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Target: IFNL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A421
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-IFNL2 Recombinant Antibody (A420) (CBMAB-AP3954LY)

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Target: IFNL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A420
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-IFNL2 Recombinant Antibody (CF236) (CBMAB-FT272LY)

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Target: IFNL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF236
Application*: ELISA, WB, IHC
Datasheet SDS

Rat Anti-IFNL2 Recombinant Antibody (CBYY-I1455) (CBMAB-I2625-YY)

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Target: IFNL2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1455
Application*: N
Datasheet SDS

Rat Anti-IFNL2 Recombinant Antibody (CBYY-I1454) (CBMAB-I2624-YY)

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Target: IFNL2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1454
Application*: BL, N
Datasheet SDS

Mouse Anti-IFNL2 Recombinant Antibody (CBYY-I1235) (CBMAB-I2404-YY)

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Target: IFNL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1235
Application*: E, WB, P
Datasheet SDS

Mouse Anti-IFNL2 Recombinant Antibody (CBYY-I1213) (CBMAB-I2382-YY)

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Target: IFNL2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-I1213
Application*: WB
Datasheet SDS

Mouse Anti-IFNL2 Recombinant Antibody (CBYY-I0714) (CBMAB-I1593-YY)

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Target: IFNL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0714
Application*: WB, E, IH, IF, IF
Datasheet SDS

Rat Anti-IFNL2 Recombinant Antibody (CBYY-I0684) (CBMAB-I1508-YY)

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Target: IFNL2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I0684
Application*: N
Datasheet SDS

Rat Anti-IFNL2 Recombinant Antibody (CBYY-I0455) (CBMAB-I1058-YY)

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Target: IFNL2
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-I0455
Application*: E, F, IH, FN, WB
Datasheet SDS

Mouse Anti-IFNL2 Recombinant Antibody (CBYY-I0110) (CBMAB-I0308-YY)

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Target: IFNL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0110
Application*: E, N
Datasheet SDS

Rat Anti-IFNL2 Recombinant Antibody (CBYY-I0109) (CBMAB-I0307-YY)

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Target: IFNL2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I0109
Application*: N, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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