IFNL2
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Full Name
Interferon Lambda 2
Function
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Biological Process
Defense response to virus Source: UniProtKB
Innate immune response Source: GO_Central
Mucosal immune response Source: UniProtKB
Positive regulation of immune response Source: InterPro
Receptor signaling pathway via JAK-STAT Source: InterPro
Innate immune response Source: GO_Central
Mucosal immune response Source: UniProtKB
Positive regulation of immune response Source: InterPro
Receptor signaling pathway via JAK-STAT Source: InterPro
Cellular Location
Secreted
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Anti-IFNL2 antibodies
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CompareTarget: IFNL2
Sensitivity: 0.0095 ng/mL
Detection Range: 0.02-3.8 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: IFNL2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-193
Tag: His Tag
Target: IFNL2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-196
Tag: His Tag
Target: IFNL2
Expressed Host: Yeast
Sequence: Amino Acid: 26-200
Tag: His Tag
Target: IFNL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4746
Application*: WB, IH
Target: IFNL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2644
Application*: IC
Target: IFNL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A542
Application*: ELISA, IHC, WB
Target: IFNL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A422
Application*: ICC, IHC, IP, WB
Target: IFNL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A421
Application*: ICC, IHC, IP, WB
Target: IFNL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A420
Application*: ICC, IHC, IP, WB
Target: IFNL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF236
Application*: ELISA, WB, IHC
Target: IFNL2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1455
Application*: N
Target: IFNL2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1454
Application*: BL, N
Target: IFNL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1235
Application*: E, WB, P
Target: IFNL2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-I1213
Application*: WB
Target: IFNL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0714
Application*: WB, E, IH, IF, IF
Target: IFNL2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I0684
Application*: N
Target: IFNL2
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-I0455
Application*: E, F, IH, FN, WB
Target: IFNL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0110
Application*: E, N
Target: IFNL2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I0109
Application*: N, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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