Mouse Anti-IFNL2 Recombinant Antibody (A422) (CBMAB-AP3967LY)

Name: Mouse Anti-IFNL2 Recombinant Antibody (A422)
SKU: CBMAB-AP3967LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A422

Application

ICC, IHC, IP, WB

Immunogen

Val26~Val200

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Interferon Lambda 2

Introduction

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

Entrez Gene ID

282616

UniProt ID

Q8IZJ0

Alternative Names

Interferon Lambda 2

Function

MAB689Hu21

Biological Process

Defense response to virus Source: UniProtKB
Innate immune response Source: GO_Central
Mucosal immune response Source: UniProtKB
Positive regulation of immune response Source: InterPro
Receptor signaling pathway via JAK-STAT Source: InterPro

Cellular Location

Secreted

Zhang, M. Q., Zhao, Q., & Zhang, J. P. (2020). A new transcription factor ATG10S activates IFNL2 transcription by binding at an IRF1 site in HepG2 cells. Autophagy, 16(12), 2167-2179.

Peterson, S. T., Kennedy, E. A., Brigleb, P. H., Taylor, G. M., Urbanek, K., Bricker, T. L., ... & Baldridge, M. T. (2019). Disruption of type III interferon (IFN) genes Ifnl2 and Ifnl3 recapitulates loss of the type III IFN receptor in the mucosal antiviral response. Journal of virology, 93(22), 10-1128.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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