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IGF2BP2

This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]
Full Name
Insulin Like Growth Factor 2 MRNA Binding Protein 2
Function
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity).

Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.
Biological Process
Anatomical structure morphogenesis Source: ProtInc
mRNA transport Source: UniProtKB-KW
Negative regulation of translation Source: BHF-UCL
Nervous system development Source: GO_Central
Regulation of cytokine production Source: BHF-UCL
Regulation of gene expression Source: GO_Central
Regulation of RNA metabolic process Source: GO_Central
Cellular Location
Cytoplasm; Nucleus. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.
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Anti-IGF2BP2 antibodies

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Mouse Anti-IGF2BP2 Recombinant Antibody (CBYY-I0929) (CBMAB-I2097-YY)

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Target: IGF2BP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0929
Application*: F, IF, WB
Datasheet SDS

Rabbit Anti-IGF2BP2 Recombinant Antibody (EG1617) (CBMAB-EN1934-LY)

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Target: IGF2BP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1617
Application*: WB: 1:500~1:1000 ELISA: 1:20000
Datasheet SDS

Mouse Anti-IGF2BP2 Recombinant Antibody (4C6) (CBMAB-A4297-LY)

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Target: IGF2BP2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4C6
Application*: WB, E
Datasheet SDS

IGF2BP2 Matched Antibody Pair (606) (APMAB-606LY)

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Target: IGF2BP2
Specificity: Human
Datasheet SDS

Mouse Anti-IGF2BP2 Recombinant Antibody (CBYY-I2110) (CBMAB-I3280-YY)

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Target: IGF2BP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBYY-I2110
Application*: WB, IF
Datasheet SDS

Mouse Anti-IGF2BP2 Recombinant Antibody (CBYY-I2073) (CBMAB-I3243-YY)

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Target: IGF2BP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBYY-I2073
Application*: IF, F
Datasheet SDS

Mouse Anti-IGF2BP2 Recombinant Antibody (CBYY-I2007) (CBMAB-I3177-YY)

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Target: IGF2BP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: CBYY-I2007
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-IGF2BP2 Recombinant Antibody (CBYY-I1938) (CBMAB-I3108-YY)

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Target: IGF2BP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: CBYY-I1938
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-IGF2BP2 Recombinant Antibody (6C4) (CBMAB-I1555-YY)

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Target: IGF2BP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 6C4
Application*: IF, WB
Datasheet SDS

Mouse Anti-IGF2BP2 Recombinant Antibody (5G3) (CBMAB-I1448-YY)

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Target: IGF2BP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 5G3
Application*: F, IF, IH, P, WB
Datasheet SDS

Mouse Anti-IGF2BP2 Recombinant Antibody (4D10) (CBMAB-I1321-YY)

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Target: IGF2BP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 4D10
Application*: WB, F, IF
Datasheet SDS

Mouse Anti-IGF2BP2 Recombinant Antibody (CBYY-I0601) (CBMAB-I1318-YY)

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Target: IGF2BP2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0601
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-IGF2BP2 Recombinant Antibody (4C4) (CBMAB-I1316-YY)

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Target: IGF2BP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: 4C4
Application*: F, IF, IH, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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