Human Recombinant IGF2BP2 protein, GST Tag (V2LY-0526-LY4666)

Name: Human Recombinant IGF2BP2 protein, GST Tag
SKU: V2LY-0526-LY4666
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant IGF2BP2 protein, GST Tag consist of Amino Acid: 1-599 and predicts a molecular mass of 94 kDa.

Molecule Mass

94 kDa

Sequence

Amino Acid: 1-599

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>76% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Insulin Like Growth Factor 2 MRNA Binding Protein 2

Function

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity).

Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.

Biological Process

Anatomical structure morphogenesis Source: ProtInc
mRNA transport Source: UniProtKB-KW
Negative regulation of translation Source: BHF-UCL
Nervous system development Source: GO_Central
Regulation of cytokine production Source: BHF-UCL
Regulation of gene expression Source: GO_Central
Regulation of RNA metabolic process Source: GO_Central

Cellular Location

Cytoplasm; Nucleus. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.

Yang, J., Qian, X., Qiu, Q., Xu, L., Pan, M., Li, J., ... & Liu, P. (2022). LCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2-CDC6 axis. Cell Death & Disease, 13(10), 877.

Weng, H., Huang, F., Yu, Z., Chen, Z., Prince, E., Kang, Y., ... & Chen, J. (2022). The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer cell, 40(12), 1566-1582.

Suo, M., Rommelfanger, M. K., Chen, Y., Amro, E. M., Han, B., Chen, Z., ... & Rudolph, K. L. (2022). Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice. Blood, The Journal of the American Society of Hematology, 139(17), 2653-2665.

Wang, J., Chen, L., & Qiang, P. (2021). The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers. Cancer Cell International, 21(1), 99.

Dai, N. (2020). The diverse functions of IMP2/IGF2BP2 in metabolism. Trends in Endocrinology & Metabolism, 31(9), 670-679.

Hu, X., Peng, W. X., Zhou, H., Jiang, J., Zhou, X., Huang, D., ... & Yang, L. (2020). IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader. Cell Death & Differentiation, 27(6), 1782-1794.

Wang, Y., Lu, J. H., Wu, Q. N., Jin, Y., Wang, D. S., Chen, Y. X., ... & Xu, R. H. (2019). LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer. Molecular cancer, 18(1), 1-18.

Li, T., Hu, P. S., Zuo, Z., Lin, J. F., Li, X., Wu, Q. N., ... & Xu, R. H. (2019). METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma. Molecular cancer, 18(1), 1-15.

Xu, X., Yu, Y., Zong, K., Lv, P., & Gu, Y. (2019). Up-regulation of IGF2BP2 by multiple mechanisms in pancreatic cancer promotes cancer proliferation by activating the PI3K/Akt signaling pathway. Journal of Experimental & Clinical Cancer Research, 38(1), 1-14.

He, X., Li, W., Liang, X., Zhu, X., Zhang, L., Huang, Y., ... & Chen, Z. (2018). IGF2BP2 overexpression indicates poor survival in patients with acute myelocytic leukemia. Cellular Physiology and Biochemistry, 51(4), 1945-1956.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

IGF2BP2 Matched Antibody Pair (606) (CAT#: APMAB-606LY)

Antibody Pairs

IGF2BP2 Matched Antibody Pair (606) (CAT#: APMAB-606LY)

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IGF2BP2 Matched Antibody Pair (606) (CAT#: APMAB-606LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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