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IL18

The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Full Name
Interleukin 18
Function
Proinflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850).

Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532).

Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850).

Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744).
Biological Process
Activation of protein kinase B activity Source: BHF-UCL
Angiogenesis Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cell population proliferation Source: Ensembl
Cellular response to organic cyclic compound Source: UniProtKB
Cholesterol homeostasis Source: BHF-UCL
Inflammatory response Source: UniProtKB
Interleukin-18-mediated signaling pathway Source: UniProtKB
Lipopolysaccharide-mediated signaling pathway Source: UniProtKB
MAPK cascade Source: UniProtKB
Natural killer cell activation Source: Ensembl
Natural killer cell mediated cytotoxicity Source: Ensembl
Negative regulation of myoblast differentiation Source: Ensembl
Neutrophil activation Source: Ensembl
Positive regulation of activated T cell proliferation Source: UniProtKB
Positive regulation of chemokine production Source: UniProtKB
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCL
Positive regulation of inflammatory response Source: BHF-UCL
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-13 production Source: UniProtKB
Positive regulation of interleukin-17 production Source: BHF-UCL
Positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Positive regulation of natural killer cell proliferation Source: BHF-UCL
Positive regulation of neuroinflammatory response Source: ARUK-UCL
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of NIK/NF-kappaB signaling Source: Ensembl
Positive regulation of NK T cell proliferation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of smooth muscle cell proliferation Source: BHF-UCL
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Positive regulation of T-helper 2 cell differentiation Source: BHF-UCL
Positive regulation of tissue remodeling Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: CACAO
Regulation of cell adhesion Source: UniProtKB
Sleep Source: UniProtKB
T-helper 1 type immune response Source: UniProtKB
Triglyceride homeostasis Source: BHF-UCL
Type 2 immune response Source: UniProtKB
Cellular Location
Cytoplasm; Secreted. The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059).
PTM
The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.

Anti-IL18 antibodies

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Target: IL18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 7BA27
Application*: E
Target: IL18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 7BA26
Application*: E, P, IH, M, WB
Target: IL18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7BA24
Application*: E, P, IH, M, WB
Target: IL18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I1100
Application*: WB, IC, P, C, E, IP, IF, F
Target: IL18
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Monkey
Clone: CBYY-I1044
Application*: E
Target: IL18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0972
Application*: E, IH, WB
Target: IL18
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-I0812
Application*: IP, NT, E
Target: IL18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse, Rat
Clone: 91D8
Application*: IP
Target: IL18
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0806
Application*: N
Target: IL18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 7G8
Application*: E, WB
Target: IL18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 74801
Application*: WB, IS, MC
Target: IL18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 74
Application*: IPP
Target: IL18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYY-I0697
Application*: WB
Target: IL18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 64G4
Application*: WB
Target: IL18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 5-C-5
Application*: E, WB
Target: IL18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 21A12
Application*: WB
Target: IL18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: 159-12B
Application*: IP, E
Target: IL18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A486
Application*: ICC, IHC, IP, WB
Target: IL18
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle
Clone: A485
Application*: ICC, IHC, IP, WB
Target: IL18
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle
Clone: A484
Application*: ICC, IHC, IP, WB
Target: IL18
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: A483
Application*: ICC, IHC, IP, WB
Target: IL18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Hamster
Clone: CF225
Application*: ELISA, IF, WB
Target: IL18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYR0257
Application*: SE
Target: IL18
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0256
Application*: SE
Target: IL18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5C7-D2-G4-B6
Application*: WB
Target: IL18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: YIGF74.1G7.C10
Application*: E, F, IP, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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