IL1F10
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Full Name
Interleukin 1 Family Member 10
Function
Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.
Biological Process
Cellular response to lipopolysaccharide Source: GO_Central
Cytokine-mediated signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Inflammatory response to antigenic stimulus Source: GO_Central
Positive regulation of gene expression Source: GO_Central
Cytokine-mediated signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Inflammatory response to antigenic stimulus Source: GO_Central
Positive regulation of gene expression Source: GO_Central
Cellular Location
Cytoplasm; Secreted. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
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Anti-IL1F10 antibodies
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CompareTarget: Il1f10
Sensitivity: 0.0053 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: IL1F10
Sensitivity: 0.011 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: IL1F10
Expressed Host: Yeast
Sequence: Amino Acid: 1-152
Tag: His Tag
Target: IL1F10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A517
Application*: ELISA, IHC
Target: IL1F10
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A516
Application*: IHC
Target: IL1F10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A515
Application*: ELISA, WB
Target: IL1F10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF228
Application*: ELISA, WB
Target: IL1F10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB274A
Application*: ELISA, IHC
Target: IL1F10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A2B3
Application*: E, IH
Target: IL1F10
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1351
Application*: E, WB
Target: IL1F10
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 798036R
Application*: WB, F
Target: IL1F10
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-I0741
Application*: WB, F, MC
Target: IL1F10
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0013
Application*: E, F, P, IP, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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