INPP5A

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq]

Full Name

inositol polyphosphate-5-phosphatase, 40kDa

Function

Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8013665, PubMed:8769125, PubMed:8626616).
Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity).

Biological Process

Inositol phosphate dephosphorylationManual Assertion Based On ExperimentIDA:MGI
Inositol phosphate metabolic processTAS:Reactome
Inositol phosphate-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of neuron deathISS:UniProtKB
Phosphatidylinositol dephosphorylationIEA:InterPro

PTM

Isoprenylation at Cys-409 is required for localization at the membrane.