ISCA1

ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM

Full Name

iron-sulfur cluster assembly 1 homolog (S. cerevisiae)

Function

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.

Biological Process

Iron-sulfur cluster assemblyManual Assertion Based On ExperimentIBA:GO_Central
Protein maturation by iron-sulfur cluster transferManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Mitochondrion

Involvement in disease

Multiple mitochondrial dysfunctions syndrome 5 (MMDS5):
An autosomal recessive, severe disorder characterized by early onset neurological deterioration, seizures, cerebral and cerebellar leukodystrophy, dysmyelination, cortical migrational abnormalities, lactic acidosis and early demise.

Anti-ISCA1 antibodies

Mouse Anti-ISCA1 Recombinant Antibody (2E9) (CBMAB-A4558-LY)

Datasheet

SDS

Target: ISCA1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2E9

Application*: WB, E

Mouse Anti-ISCA1 Recombinant Antibody (CBFYH-2597) (CBMAB-H3622-FY)

Datasheet

SDS

Target: ISCA1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYH-2597

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)