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ISCA1

ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM

Full Name

iron-sulfur cluster assembly 1 homolog (S. cerevisiae)

Function

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.

Biological Process

Iron-sulfur cluster assemblyManual Assertion Based On ExperimentIBA:GO_Central
Protein maturation by iron-sulfur cluster transferManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Mitochondrion

Involvement in disease

Multiple mitochondrial dysfunctions syndrome 5 (MMDS5):
An autosomal recessive, severe disorder characterized by early onset neurological deterioration, seizures, cerebral and cerebellar leukodystrophy, dysmyelination, cortical migrational abnormalities, lactic acidosis and early demise.

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Anti-ISCA1 antibodies

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Mouse Anti-ISCA1 Recombinant Antibody (CBFYH-2597) (CBMAB-H3622-FY)

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Target: ISCA1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYH-2597

Application*: WB

Mouse Anti-ISCA1 Recombinant Antibody (2E9) (CBMAB-A4558-LY)

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Target: ISCA1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2E9

Application*: WB, E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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