KCNIP1
This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms.
Full Name
potassium voltage-gated channel interacting protein 1
Function
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface.
Biological Process
Regulation of potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane; Cytoplasm; Cell projection, dendrite
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Anti-KCNIP1 antibodies
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CompareTarget: KCNIP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-050
Application*: WB, IP, F
Target: KCNIP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Mouse, Human
Clone: S55-82
Application*: C, IF, IP, WB
Target: KCNIP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human, Mouse
Clone: S55-7
Application*: IH, C, IP
Target: KCNIP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D9
Application*: E, WB
Target: KCNIP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D6C1
Application*: E, WB, IH
Target: KCNIP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11E2
Application*: WB
Target: KCNIP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1742
Application*: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:20000
Target: KCNIP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A735
Application*: ELISA, IHC, WB
Target: KCNIP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1076
Application*: WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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