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Mouse Anti-KCNIP1 Recombinant Antibody (S55-7) (CBMAB-K0544-LY)

This product is antibody recognizes KCNIP1. The antibody S55-7 immunoassay techniques such as: IHC, IHC-Fr, IP.
See all KCNIP1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Human, Mouse
Clone
S55-7
Antibody Isotype
IgG1
Application
IHC, IHC-Fr, IP

Basic Information

Immunogen
Fusion protein amino acids 1-216 (Full lenght) of rat KChIPIb
Specificity
Rat, Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
potassium voltage-gated channel interacting protein 1
Introduction
This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Entrez Gene ID
Human30820
Mouse70357
Rat65023
UniProt ID
HumanQ9NZI2
MouseQ9JJ57
RatQ8R426
Alternative Names
Kchip1
Function
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface.
Biological Process
Regulation of potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane; Cytoplasm; Cell projection, dendrite
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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