KCNIP2

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq]

Full Name

Kv channel interacting protein 2

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).

Biological Process

Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Clustering of voltage-gated potassium channelsManual Assertion Based On ExperimentIDA:UniProtKB
Detection of calcium ionManual Assertion Based On ExperimentTAS:ProtInc
Membrane repolarizationManual Assertion Based On ExperimentIDA:BHF-UCL
Membrane repolarization during cardiac muscle cell action potentialManual Assertion Based On ExperimentTAS:BHF-UCL
Muscle contraction1 PublicationNAS:UniProtKB
Positive regulation of potassium ion export across plasma membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of voltage-gated potassium channel activityManual Assertion Based On ExperimentTAS:BHF-UCL
Potassium ion export across plasma membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Potassium ion transportManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of heart contractionManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Isoform 1&2&6: Cell membrane

PTM

Palmitoylated. Palmitoylation enhances association with the plasma membrane.