Mouse Anti-KCNIP2 Recombinant Antibody (10F10) (CBMAB-K0546-LY)

This product is antibody recognizes KCNIP2. The antibody 10F10 immunoassay techniques such as: WB.
See all KCNIP2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

10F10

Antibody Isotype

IgG1

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Kv channel interacting protein 2

Introduction

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

30819

UniProt ID

Q9NS61

Alternative Names

Potassium Voltage-Gated Channel Interacting Protein 2; Cardiac Voltage-Gated Potassium Channel Modulatory Subunit; A-Type Potassium Channel Modulatory Protein 2; Potassium Channel-Interacting Protein 2; Kv Channel-Interacting Protein 2; KCHIP2; Kv Channel Interacting Protein 2;

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).

Biological Process

Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Clustering of voltage-gated potassium channelsManual Assertion Based On ExperimentIDA:UniProtKB
Detection of calcium ionManual Assertion Based On ExperimentTAS:ProtInc
Membrane repolarizationManual Assertion Based On ExperimentIDA:BHF-UCL
Membrane repolarization during cardiac muscle cell action potentialManual Assertion Based On ExperimentTAS:BHF-UCL
Muscle contraction1 PublicationNAS:UniProtKB
Positive regulation of potassium ion export across plasma membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of voltage-gated potassium channel activityManual Assertion Based On ExperimentTAS:BHF-UCL
Potassium ion export across plasma membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Potassium ion transportManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of heart contractionManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Isoform 1&2&6: Cell membrane

PTM

Palmitoylated. Palmitoylation enhances association with the plasma membrane.

References

Qiu, H., Miraucourt, L., & Sharif-Naeini, R. (2023). Spinal processing of cold information by Kcnip2 neurons. Neuron, 111(1), 8-9.

Albisetti, G. W., Ganley, R. P., Pietrafesa, F., Werynska, K., de Sousa, M. M., Sipione, R., ... & Zeilhofer, H. U. (2023). Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold. Neuron, 111(1), 92-105.

Zhang, X., Liao, C., Sun, K., Liu, L., & Xu, D. (2020, August). A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction. In The Heart Surgery Forum (Vol. 23, No. 5, pp. E579-E585).

Albisetti, G. W. (2019). Functional diversity of spinal cord interneurons: roles of GRP-neurons in itch and KCNIP2-neurons in cold processing circuits (Doctoral dissertation, University of Zurich).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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