KIF2C

This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants.
Full Name
kinesin family member 2C
Function
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309).
Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894).
Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).
Biological Process
Attachment of mitotic spindle microtubules to kinetochoreManual Assertion Based On ExperimentIMP:UniProtKB
Cell divisionIEA:UniProtKB-KW
Establishment or maintenance of microtubule cytoskeleton polarityManual Assertion Based On ExperimentIMP:HGNC-UCL
Metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule depolymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton; Nucleus; Chromosome, centromere; Chromosome, centromere, kinetochore. Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity).
Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2.
PTM
Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.
Ubiquitinated.
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Anti-KIF2C antibodies

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Mouse Anti-KIF2C Antibody (8BA9) (CBMAB-1365CQ)

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Target: KIF2C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8BA9
Application*: E, WB
Datasheet SDS

Mouse Anti-KIF2C Recombinant Antibody (8C205) (CBMAB-K0878-LY)

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Target: KIF2C
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 8C205
Application*: WB
Datasheet SDS

Mouse Anti-KIF2C Recombinant Antibody (2488C3a) (CBMAB-K0877-LY)

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Target: KIF2C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2488C3a
Application*: DB, F, IC, WB
Datasheet SDS

Mouse Anti-KIF2C Recombinant Antibody (1G2) (CBMAB-K0876-LY)

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Target: KIF2C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G2
Application*: IF, WB
Datasheet SDS

Mouse Anti-KIF2C Recombinant Antibody (1C5) (CBMAB-K0875-LY)

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Target: KIF2C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C5
Application*: F
Datasheet SDS

Rabbit Anti-KIF2C Recombinant Antibody (EG1791) (CBMAB-EN2139-LY)

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Target: KIF2C
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG1791
Application*: IF: 1:100~1:500 ELISA: 1:1000
Datasheet SDS

KIF2C Matched Antibody Pair (664) (APMAB-664LY)

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Target: KIF2C
Specificity: Human
Datasheet SDS

Mouse Anti-KIF2C Recombinant Antibody (CBFYM-1180) (CBMAB-M1337-FY)

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Target: KIF2C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1180
Application*: WB, DB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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