Mouse Anti-KIF2C Recombinant Antibody (2488C3a) (CBMAB-K0877-LY)

Name: Mouse Anti-KIF2C Recombinant Antibody (2488C3a)
SKU: CBMAB-K0877-LY
Rating: 5 (1 reviews)

See all KIF2C antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2488C3a

Application

Dot Blot, FC, ICC, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

1% BSA

Preservative

0.05% sodium azide

Concentration

0.1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

kinesin family member 2C

Introduction

This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Entrez Gene ID

11004

UniProt ID

Q99661

Alternative Names

Kinesin Family Member 2C; Mitotic Centromere-Associated Kinesin; Kinesin-Like Protein 6; KNSL6; MCAK; Kinesin-Like 6 (Mitotic Centromere-Associated Kinesin); Testis Tissue Sperm-Binding Protein Li 68n; Kinesin-Like Protein KIF2C; CT139;

Function

In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309).
Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894).
Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).

Biological Process

Attachment of mitotic spindle microtubules to kinetochoreManual Assertion Based On ExperimentIMP:UniProtKB
Cell divisionIEA:UniProtKB-KW
Establishment or maintenance of microtubule cytoskeleton polarityManual Assertion Based On ExperimentIMP:HGNC-UCL
Metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule depolymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton; Nucleus; Chromosome, centromere; Chromosome, centromere, kinetochore. Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity).
Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2.

PTM

Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.
Ubiquitinated.

Li, S., Ma, Y., Wu, C., & Hou, X. (2023). Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer.

Zhang, B., Li, Y., Pang, X., & Wu, H. (2022). Bioinformatics analysis of kinesin family member 2C in human tumors: novel prognostic biomarker and tumor microenvironment regulator.

Yang, J., Wu, Z., Yang, L., Jeong, J. H., Zhu, Y., Lu, J., ... & Li, R. (2022). Characterization of kinesin family member 2C as a proto-oncogene in cervical cancer. Frontiers in Pharmacology, 12, 785981.

Zhang, B., Liu, P., Li, Y., Hu, Q., Li, H., Pang, X., & Wu, H. (2022). Multi-omics analysis of kinesin family member 2C in human tumors: novel prognostic biomarker and tumor microenvironment regulator. American Journal of Cancer Research, 12(11), 4954.

Mo, S., Fang, D., Zhao, S., Hoa, P. T. T., Zhou, C., Liang, T., ... & Han, C. (2022). Down regulated oncogene KIF2C inhibits growth, invasion, and metastasis of hepatocellular carcinoma through the Ras/MAPK signaling pathway and epithelial-to-mesenchymal transition. Annals of Translational Medicine, 10(3).

Ding, Q., Jiang, C., Zhou, Y., Duan, J., Lai, J., Jiang, M., & Lin, D. (2021). Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway. Bioscience, Biotechnology, and Biochemistry, 85(11), 2241-2249.

Li, X., Huang, W., Huang, W., Wei, T., Zhu, W., Chen, G., & Zhang, J. (2020). Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma. American Journal of Translational Research, 12(5), 1614.

Zhu, S., Paydar, M., Wang, F., Li, Y., Wang, L., Barrette, B., ... & Peng, A. (2020). Kinesin Kif2C in regulation of DNA double strand break dynamics and repair. Elife, 9, e53402.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-KIF2C Recombinant Antibody (2488C3a)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

KIF2C Matched Antibody Pair (664) (CAT#: APMAB-664LY)

Related Products

Mouse Anti-KIF2C Recombinant Antibody (1G2) (CAT#: CBMAB-K0876-LY)

Mouse Anti-KIF2C Recombinant Antibody (1C5) (CAT#: CBMAB-K0875-LY)

Mouse Anti-KIF2C Antibody (8BA9) (CAT#: CBMAB-1365CQ)

KIF2C Matched Antibody Pair (664) (CAT#: APMAB-664LY)

Mouse Anti-KIF2C Recombinant Antibody (CBFYM-1180) (CAT#: CBMAB-M1337-FY)

Mouse Anti-KIF2C Recombinant Antibody (8C205) (CAT#: CBMAB-K0878-LY)

Rabbit Anti-KIF2C Recombinant Antibody (EG1791) (CAT#: CBMAB-EN2139-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry