KLF10
This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants.
Full Name
KLF10
Function
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity).
May play a role in the cell cycle regulation.
May play a role in the cell cycle regulation.
Biological Process
Bone mineralizationIEA:Ensembl
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to starvationISS:UniProtKB
Circadian rhythmIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Positive regulation of osteoclast differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of circadian rhythmISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Somatic stem cell population maintenanceIEA:Ensembl
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to starvationISS:UniProtKB
Circadian rhythmIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Positive regulation of osteoclast differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of circadian rhythmISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Somatic stem cell population maintenanceIEA:Ensembl
Cellular Location
Nucleus
PTM
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
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Anti-KLF10 antibodies
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CompareTarget: KLF10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4B1
Application*: IP, M
Target: KLF10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D3
Application*: CI, IP, WB, M
Target: KLF10
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-107
Application*: WB
Target: KLF10
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4G9
Application*: IF, WB
Target: KLF10
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H3
Application*: E, WB
Target: KLF10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1G2
Application*: IP, M
Target: KLF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D6
Application*: IP, WB, M
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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