Sign in or Register   Sign in or Register
  |  

Rabbit Anti-KLF10 Recombinant Antibody (CBLY1-107) (CBMAB-K1040-LY)

This product is antibody recognizes KLF10. The antibody CBLY1-107 immunoassay techniques such as: WB.
See all KLF10 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBLY1-107
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.107 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
KLF10
Introduction
This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Entrez Gene ID
Human7071
Mouse21847
Rat81813
UniProt ID
HumanQ13118
MouseO89091
RatO08876
Function
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity).
May play a role in the cell cycle regulation.
Biological Process
Bone mineralizationIEA:Ensembl
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to starvationISS:UniProtKB
Circadian rhythmIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Positive regulation of osteoclast differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of circadian rhythmISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Somatic stem cell population maintenanceIEA:Ensembl
Cellular Location
Nucleus
PTM
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.

Luo, H. Y., Zhu, J. Y., Chen, M., Mu, W. J., & Guo, L. (2023). Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes. Genes & Diseases, 10(3), 915-930.

Memon, A., Pyao, Y., Jung, Y., Choi, H. S., Song, K. D., & Lee, W. K. (2021). The basal transcriptional activity of the murine Klf10 gene is regulated by the transcriptional factor JunB. Genes & Genomics, 43, 343-349.

You, M., Zhang, L., Zhang, X., Fu, Y., & Dong, X. (2021). MicroRNA-197-3p inhibits the osteogenic differentiation in osteoporosis by down-regulating KLF 10. Clinical Interventions in Aging, 107-117.

Lee, J., Oh, A. R., Lee, H. Y., Moon, Y. A., Lee, H. J., & Cha, J. Y. (2020). Deletion of KLF10 leads to stress-induced liver fibrosis upon high sucrose feeding. International Journal of Molecular Sciences, 22(1), 331.

Lin, C. L., Hsu, Y. C., Huang, Y. T., Shih, Y. H., Wang, C. J., Chiang, W. C., & Chang, P. J. (2019). A KDM6A–KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction. EMBO molecular medicine, 11(5), e9828.

DiMario, J. X. (2018). KLF10 gene expression modulates fibrosis in dystrophic skeletal muscle. The American journal of pathology, 188(5), 1263-1275.

Liu, Y., Peng, W. Q., Guo, Y. Y., Liu, Y., Tang, Q. Q., & Guo, L. (2018). Krüppel-like factor 10 (KLF10) is transactivated by the transcription factor C/EBPβ and involved in early 3T3-L1 preadipocyte differentiation. Journal of Biological Chemistry, 293(36), 14012-14021.

Memon, A., & Lee, W. K. (2018). KLF10 as a tumor suppressor gene and its TGF-β signaling. Cancers, 10(6), 161.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-KLF10 Recombinant Antibody (CBLY1-107)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare