KLF2

This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability.

Full Name

Kruppel-like factor 2 (lung)

Function

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504).
Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758).

Biological Process

Cell morphogenesisIEA:Ensembl
Cellular response to cycloheximideIEA:Ensembl
Cellular response to fluid shear stressManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to hydrogen peroxideIEA:Ensembl
Cellular response to interleukin-1IEA:Ensembl
Cellular response to laminar fluid shear stressManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to peptideIEA:Ensembl
Cellular response to tumor necrosis factorIEA:Ensembl
Cellular stress response to acid chemicalManual Assertion Based On ExperimentIMP:BHF-UCL
Erythrocyte maturationIEA:Ensembl
In utero embryonic developmentIEA:Ensembl
Multicellular organism growthIEA:Ensembl
Negative regulation of interleukin-6 productionIEA:Ensembl
Negative regulation of sprouting angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of nitric oxide biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of protein metabolic processManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of retinoic acid receptor signaling pathwayManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transcription from RNA polymerase II promoter in response to stressManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of gene expression, epigeneticIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Type I pneumocyte differentiationIEA:Ensembl
VasodilationManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Nucleus

PTM

Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity).