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Mouse Anti-KLF2 Recombinant Antibody (11n121) (CBMAB-K1076-LY)

This product is antibody recognizes KLF2. The antibody 11n121 immunoassay techniques such as: ICC.
See all KLF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
11n121
Antibody Isotype
IgG2b
Application
ICC

Basic Information

Immunogen
Recombinant corresponding to aa71-168 from human KLF2 (predicted) expressed in E. coli (Q9Y5W3)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kruppel-like factor 2 (lung)
Introduction
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017]
Entrez Gene ID
UniProt ID
Alternative Names
Kruppel Like Factor 2; Kruppel-Like Factor 2 (Lung); Lung Krueppel-Like Factor; Lung Kruppel-Like Factor; LKLF; Lung Kruppel-Like Zinc Finger Transcription Factor; Kruppel-Like Factor LKLF; Krueppel-Like Factor 2;
Function
Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504).
Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758).
Biological Process
Cell morphogenesisIEA:Ensembl
Cellular response to cycloheximideIEA:Ensembl
Cellular response to fluid shear stressManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to hydrogen peroxideIEA:Ensembl
Cellular response to interleukin-1IEA:Ensembl
Cellular response to laminar fluid shear stressManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to peptideIEA:Ensembl
Cellular response to tumor necrosis factorIEA:Ensembl
Cellular stress response to acid chemicalManual Assertion Based On ExperimentIMP:BHF-UCL
Erythrocyte maturationIEA:Ensembl
In utero embryonic developmentIEA:Ensembl
Multicellular organism growthIEA:Ensembl
Negative regulation of interleukin-6 productionIEA:Ensembl
Negative regulation of sprouting angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of nitric oxide biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of protein metabolic processManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of retinoic acid receptor signaling pathwayManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transcription from RNA polymerase II promoter in response to stressManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of gene expression, epigeneticIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Type I pneumocyte differentiationIEA:Ensembl
VasodilationManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Nucleus
PTM
Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity).

Kawata, M., Teramura, T., Ordoukhanian, P., Head, S. R., Natarajan, P., Sundaresan, A., ... & Lotz, M. K. (2022). Krüppel-like factor-4 and Krüppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis. Annals of the Rheumatic Diseases, 81(8), 1179-1188.

Li, R., Chen, J., Gao, X., & Jiang, G. (2021). Transcription factor KLF2 enhances the sensitivity of breast cancer cells to cisplatin by suppressing kinase WEE1. Cancer Biology & Therapy, 22(7-9), 465-477.

Xu, S., Liu, Y., Ding, Y., Luo, S., Zheng, X., Wu, X., ... & Weng, J. (2021). The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction. Signal Transduction and Targeted Therapy, 6(1), 266.

Li, S., Zheng, X., Huang, C., & Cao, Y. (2021). Titanate nanofibers reduce Kruppel-like factor 2 (KLF2)-eNOS pathway in endothelial monolayer: A transcriptomic study. Chinese Chemical Letters, 32(4), 1567-1570.

Rolph, D., & Das, H. (2020). Transcriptional regulation of osteoclastogenesis: the emerging role of KLF2. Frontiers in immunology, 11, 937.

Fan, Y., Wang, D., Rao, C., Li, Y., Rong, H., Wang, Z., & Zhang, J. (2020). Atorvastatin combined with low-dose dexamethasone treatment protects endothelial function impaired by chronic subdural hematoma via the transcription factor KLF-2. Drug design, development and therapy, 3291-3299.

Turpaev, K. T. (2020). Transcription factor KLF2 and its role in the regulation of inflammatory processes. Biochemistry (Moscow), 85, 54-67.

Hou, Z., Wang, Z., Tao, Y., Bai, J., Yu, B., Shen, J., ... & Geng, D. (2019). KLF2 regulates osteoblast differentiation by targeting of Runx2. Laboratory Investigation, 99(2), 271-280.

Rasouli, S. J., El-Brolosy, M., Tsedeke, A. T., Bensimon-Brito, A., Ghanbari, P., Maischein, H. M., ... & Stainier, D. Y. (2018). The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling. Elife, 7, e38889.

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For research use only. Not intended for any clinical use.

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