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KRT18

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
Keratin 18
Function
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity).
When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Biological Process
Anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cell cycleIEA:UniProtKB-KW
Extrinsic apoptotic signaling pathwayIEA:Ensembl
Golgi to plasma membrane CFTR protein transportManual Assertion Based On ExperimentIDA:UniProtKB
Hepatocyte apoptotic processIEA:Ensembl
Intermediate filament cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Tumor necrosis factor-mediated signaling pathwayIEA:Ensembl
Cellular Location
Cytoplasm, perinuclear region
Nucleus, nucleolus
Involvement in disease
Cirrhosis (CIRRH):
A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
PTM
Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.
O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.

Anti-KRT18 antibodies

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Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Dog, Hamster, Human, Mouse, Pig, Rat, Sheep
Clone: CBFYC-2885
Application*: E, IH, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Dog, Hamster, Human, Mouse, Pig, Rat, Sheep
Clone: CBFYC-2884
Application*: F, IH
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A813
Application*: IF, IHC, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: A812
Application*: ICC, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: A811
Application*: ELISA, ICC, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A810
Application*: ELISA, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A809
Application*: ELISA, IF, IHC, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A808
Application*: ELISA, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A807
Application*: ICC, IHC, IP, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: A806
Application*: ICC, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Pig
Clone: A805
Application*: ELISA, FC, IF, IHC, IP, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A804
Application*: IF, IHC, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBCNC-633
Application*: E, WB, P, IF
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: BS83
Application*: P
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q1118
Application*: FC, IF, IH, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A801
Application*: IHC, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: A800
Application*: Dot blot, ELISA, IF, IHC, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CY-90
Application*: IHC, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP924
Application*: WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CAP923
Application*: WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP922
Application*: WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CAP921
Application*: ICC, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 9A6
Application*: WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 560
Application*: ELISA, IF, IHC, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5D1
Application*: IHC
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB237A
Application*: ELISA, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CB235A
Application*: ELISA, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB234A
Application*: ELISA, WB, IHC, IF
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB300
Application*: WB, IF/ICC
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB299
Application*: WB, IHC
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CB298
Application*: WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7I6
Application*: FC, IF, IHC-P, IHC-F, ICC, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBAb148
Application*: WB, IC
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: IHC018
Application*: P, E, IH
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLC229-LY
Application*: WB, IP, IF, E
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Cattle, Dog, Pig, Sheep, Hamster
Clone: SPM265
Application*: WB, P, IF/IC, F
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: RCK106
Application*: F, IC, IH, C, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 13B210
Application*: E, IH, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: 8F2
Application*: WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 810811
Application*: WB, IH, IC
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 6B3
Application*: WB, IF
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5G6
Application*: WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse
Clone: 5G4
Application*: IH, IP, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit
Clone: 5F297
Application*: IF, C, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human
Clone: 5F228
Application*: E, C, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5E8/CK-18
Application*: IH
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4A34
Application*: F, IC, C, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Chicken, Hamster, Human, Mouse, Pig, Rabbit, Rat
Clone: 4A33
Application*: F, IC, C, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 3H6
Application*: WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 10K180
Application*: IF, IH, IP, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: 1B3
Application*: WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: UMAB50
Application*: P
Target: KRT18
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP69
Application*: P
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle
Clone: sKs18.04/18.27/18.5/9B1/18.174
Application*: IH, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Rabbit, Dog, Pig, Chicken
Clone: RGE53
Application*: IH, IF, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: 6-19
Application*: WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: 2B5-B6-F7
Application*: WB, IC
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CTKN18-1
Application*: IF, P
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: Cocktail
Application*: P, IF/IC, F
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CK-18
Application*: C, P, WB
Target: KRT18
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: R20-H
Application*: P, C
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: PAT2G3AT
Application*: E, WB, IF
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M9
Application*: IF, C, P, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: M80525
Application*: WB, IC
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ks18-5
Application*: E, IH, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: Ks18.27
Application*: E, IH, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: KRT18Cocktail
Application*: F, IF, P
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2F7
Application*: WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F8
Application*: IF, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Cat
Clone: KRT18/836
Application*: P, IF/IC, F
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Cattle, Dog, Pig, Sheep, Hamster
Clone: KRT18/834
Application*: P, IF/IC, F
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: KRT18/1190
Application*: P, IF/IC, F
Target: KRT18
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E431-1
Application*: P
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cat, Dog
Clone: DE-K18
Application*: WB, IH, IC, F
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DC-10
Application*: E, WB, IH, IC, IP, F
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DA-7
Application*: E, IC, IH, IP, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 695CT17.2.6
Application*: WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat, Cattle, Dog, Pig, Sheep, Hamster
Clone: DA7
Application*: WB, P, IF/IC, F
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CY90
Application*: C, P
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C11
Application*: WB, IP, P, IC, F
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ks 18.04
Application*: F, C, P
Target: KRT18
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-147
Application*: WB, IP, IC/IF
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10G8
Application*: WB, IH
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 11H2
Application*: E, IC, IF, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 13H295
Application*: E, IF, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Cattle
Clone: 16k205
Application*: E, IH, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E1
Application*: IF, P, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G11C4
Application*: E, F, IF, IH, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1G8
Application*: E, IF, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H10
Application*: IH
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2Q1070
Application*: P, C
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D1
Application*: IH, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H2059
Application*: IH
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 4B11
Application*: IH, IP, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4D11E4
Application*: WB, IH, E
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog
Clone: 5E8
Application*: IH, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: AT2G3
Application*: E, IF, WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Cattle, Dog, Pig, Sheep, Hamster
Clone: B23.1
Application*: WB, P, IF/IC, F
Target: KRT18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3C3
Application*: WB
Target: KRT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C-04
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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