LAMTOR4

LAMTOR4 (Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4) is a Protein Coding gene. Among its related pathways are Gene Expression and RET signaling. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and protein-containing complex scaffold activity.

Full Name

Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4

Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.

Biological Process

Cellular response to amino acid stimulusManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Protein localization to lysosomeManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of catalytic activityIEA:GOC
Regulation of cell sizeManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Lysosome