Rabbit Anti-LAMTOR4 Recombinant Antibody (CBWJC-4119) (CBMAB-C5463WJ)

Name: Rabbit Anti-LAMTOR4 Recombinant Antibody (CBWJC-4119)
SKU: CBMAB-C5463WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBWJC-4119

Application

WB, IP, IF

Specificity

Human, Mouse, Rat, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4

Introduction

LAMTOR4 (Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4) is a Protein Coding gene. Among its related pathways are Gene Expression and RET signaling. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and protein-containing complex scaffold activity.

Entrez Gene ID

Human	389541
Mouse	66096
Rat	360776
Monkey	719122

UniProt ID

Human	Q0VGL1
Mouse	Q8CF66
Rat	D4AD29
Monkey	G7P0C8

Alternative Names

C7orf59

Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.

Biological Process

Cellular response to amino acid stimulusManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Protein localization to lysosomeManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of catalytic activityIEA:GOC
Regulation of cell sizeManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Lysosome

Zhang, S., Lee, S. H., Nie, L., Huang, Y., Zou, G., Jung, Y. S., ... & Park, J. I. (2023). Lysosomal TMEM9‐LAMTOR4‐controlled mTOR signaling integrity is required for mammary tumorigenesis. Cancer Communications, 43(1), 159.

Rasheed, N., Lima, T. B., Mercaldi, G. F., Nascimento, A. F., Silva, A. L., Righetto, G. L., ... & Smetana, J. H. (2019). C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly. FEBS open bio, 9(9), 1589-1602.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-LAMTOR4 Recombinant Antibody (CBWJC-4118) (CAT#: CBMAB-C5462WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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