LAR

Leukocyte-antigen-related-like (Lar) is a transmembrane receptor tyrosine phosphatase whose extracellular domain binds to Sdc. Lar regulates signaling through Abl. While Lar has many functions, it is best known for its roles in embryonic motor axon guidance and in target recognition by axons of R7 photoreceptors. It possesses an intrinsic protein tyrosine phosphatase activity.

Full Name

Leukocyte-antigen-related-like

Function

Possible cell adhesion receptor (Probable). It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (PubMed:2554325).
It controls motor axon guidance (PubMed:8598047).
In the developing eye, has a role in normal axonal targeting of the R7 photoreceptor, where it negatively regulates bdl (PubMed:24174674).
Inhibits bdl cell adhesion activity in vitro; this effect is independent of its PTPase function (PubMed:24174674).

Biological Process

Axon extensionManual Assertion Based On ExperimentIMP:FlyBase
Axon guidanceManual Assertion Based On ExperimentIMP:FlyBase
Axon target recognitionManual Assertion Based On ExperimentIMP:FlyBase
Cell adhesionIEA:UniProtKB-KW
Centripetally migrating follicle cell migrationManual Assertion Based On ExperimentIMP:FlyBase
Hematopoietic stem cell homeostasisManual Assertion Based On ExperimentIMP:FlyBase
Motor neuron axon guidanceManual Assertion Based On ExperimentIMP:FlyBase
Negative regulation of homophilic cell adhesionManual Assertion Based On ExperimentIGI:FlyBase
Negative regulation of insulin receptor signaling pathwayManual Assertion Based On ExperimentIMP:FlyBase
Nervous system developmentManual Assertion Based On ExperimentIMP:FlyBase
OogenesisManual Assertion Based On ExperimentIMP:FlyBase
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIDA:FlyBase
Photoreceptor cell morphogenesisManual Assertion Based On ExperimentIMP:FlyBase
Positive regulation of filopodium assemblyManual Assertion Based On ExperimentIMP:FlyBase
Positive regulation of plasma membrane bounded cell projection assemblyManual Assertion Based On ExperimentIMP:FlyBase
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
R7 cell developmentManual Assertion Based On ExperimentIMP:FlyBase
Regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIMP:FlyBase
Retinal ganglion cell axon guidanceManual Assertion Based On ExperimentIMP:FlyBase
SpermatogenesisManual Assertion Based On ExperimentIMP:FlyBase
Synaptic assembly at neuromuscular junctionManual Assertion Based On ExperimentIMP:FlyBase

Cellular Location

Membrane

Topology

Extracellular: 33-1377
Helical: 1378-1402
Cytoplasmic: 1403-2029