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Mouse Anti-LAR Recombinant Antibody (9D82B3) (CBMAB-0324-CN)

This product is a mouse antibody that recognizes LAR of Drosophila. The antibody 9D82B3 can be used for immunoassay techniques such as: IF, IHC, IP.
See all LAR antibodies

Summary

Host Animal
Mouse
Specificity
Common fruit fly
Clone
9D82B3
Antibody Isotype
IgG1
Application
IF, IHC, IP

Basic Information

Immunogen
Native DLAR
Specificity
Common fruit fly
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Leukocyte-antigen-related-like
Introduction
Leukocyte-antigen-related-like (Lar) is a transmembrane receptor tyrosine phosphatase whose extracellular domain binds to Sdc. Lar regulates signaling through Abl. While Lar has many functions, it is best known for its roles in embryonic motor axon guidance and in target recognition by axons of R7 photoreceptors. It possesses an intrinsic protein tyrosine phosphatase activity.
Entrez Gene ID
35259
UniProt ID
P16621
Alternative Names
CG10443; dlar; Dlar; DLar; DLAR; Dmel\CG10443; lar; LAR; Ptp38A; PTP38A
Function
Possible cell adhesion receptor (Probable). It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (PubMed:2554325).
It controls motor axon guidance (PubMed:8598047).
In the developing eye, has a role in normal axonal targeting of the R7 photoreceptor, where it negatively regulates bdl (PubMed:24174674).
Inhibits bdl cell adhesion activity in vitro; this effect is independent of its PTPase function (PubMed:24174674).
Biological Process
Axon extensionManual Assertion Based On ExperimentIMP:FlyBase
Axon guidanceManual Assertion Based On ExperimentIMP:FlyBase
Axon target recognitionManual Assertion Based On ExperimentIMP:FlyBase
Cell adhesionIEA:UniProtKB-KW
Centripetally migrating follicle cell migrationManual Assertion Based On ExperimentIMP:FlyBase
Hematopoietic stem cell homeostasisManual Assertion Based On ExperimentIMP:FlyBase
Motor neuron axon guidanceManual Assertion Based On ExperimentIMP:FlyBase
Negative regulation of homophilic cell adhesionManual Assertion Based On ExperimentIGI:FlyBase
Negative regulation of insulin receptor signaling pathwayManual Assertion Based On ExperimentIMP:FlyBase
Nervous system developmentManual Assertion Based On ExperimentIMP:FlyBase
OogenesisManual Assertion Based On ExperimentIMP:FlyBase
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIDA:FlyBase
Photoreceptor cell morphogenesisManual Assertion Based On ExperimentIMP:FlyBase
Positive regulation of filopodium assemblyManual Assertion Based On ExperimentIMP:FlyBase
Positive regulation of plasma membrane bounded cell projection assemblyManual Assertion Based On ExperimentIMP:FlyBase
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
R7 cell developmentManual Assertion Based On ExperimentIMP:FlyBase
Regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIMP:FlyBase
Retinal ganglion cell axon guidanceManual Assertion Based On ExperimentIMP:FlyBase
SpermatogenesisManual Assertion Based On ExperimentIMP:FlyBase
Synaptic assembly at neuromuscular junctionManual Assertion Based On ExperimentIMP:FlyBase
Cellular Location
Membrane
Topology
Extracellular: 33-1377
Helical: 1378-1402
Cytoplasmic: 1403-2029
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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